Results 41 to 50 of about 1,231,487 (219)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Using a flipped classroom teaching and learning approach to promote scientific literacy skill development and retention

FEBS Open Bio
The development of scientific literacy (SL) skills is critical in the life sciences. A flipped classroom reverses traditional learning spaces such that foundational knowledge is acquired by students independently through recorded lectures and/or readings
Elaina B. K. Brendel, Ala Alzubi, Shrujan Rai, Christine Mariathasan, Laelie A. Snook, Jennifer M. Monk   +5 more
doaj   +1 more source

Investigating the effects of personality on academic performance in higher education

Cogent Education
The effects of the direct and indirect relationships of personality traits on academic performance are shared in this paper. These complex relationships are examined using Structural Equation Modelling (SEM) with reference to the modified Biggs’ 3P model.
Jess Wei Chin Tan, Horn Mun Cheah, Hian Chye Koh   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Effects of a Personalized Navigation Support Approach on Students’ Context-Aware Ubiquitous Learning Performances

Educational Technology & Society, 2019
In context-aware ubiquitous learning, the learning resources of the learning environment are limited, and the learners need to frequently move between learning targets.
Effects of a Personalized Navigation Support Approach on Students’ Context-Aware Ubiquitous Learning Performances , Chuang-Kai Chiu, Judy C. R. Tseng   +2 more
doaj  

The inclusion of psychological factors in the evaluation of a curriculum enrichment program for students with high ability

Frontiers in Psychology
There is currently evidence of the importance of some psychological factors in long-term academic performance. In this study, the impact that a curriculum enrichment program has had on academic performance has been evaluated considering psychological ...
Leire Aperribai, Garbiñe Moreno, Ainize Sarrionandia, Karmele Salaberria   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

CTL-Deep learning: Its influence on critical thinking skills and self-confidence in linear equation system material

Jurnal Math Educator Nusantara: Wahana Publikasi Karya Tulis Ilmiah di Bidang Pendidikan Matematika
Many senior high school students have difficulty in understanding Linear Equation Systems (LES). The Contextual Teaching and Learning-Deep Learning (CTL-DL) approach is one of the current solutions.
Amelia Anggraini, Elly Arliani
doaj   +1 more source