Results 81 to 90 of about 14,065,891 (304)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Expression and connection : the integration of the reflective learning process and the writing process into social network sites [PDF]

open access: yes, 2011
A number of instructors have recently adopted social network sites (SNSs) for learning. However, the learning design of SNSs often remains at a preliminary level similar to a personal log book because it does not properly include reflective learning ...
Son, Jeong-Bae, Park, Ji Yong
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

The professional learning of Scotland’s Adult Educators

open access: yes, 2018
First paragraph: Following the publication of Adult Learning in Scotland: Statement of Ambition in 2014, four national working groups were set up to take forward the Scottish Government’s vision to establish world leading adult learning in Scotland. This
Galloway, Sarah
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

SOCIOCULTURAL SPHERES OF LIFE OF THE BELARUSIAN LANGUAGE IN THE CONTEXT OF TWO STATE LANGUAGES

open access: yesPolylinguality and Transcultural Practices, 2017
The Belarusian and Russian languages have equal status in the Republic of Belarus. Both of them are used in the media sphere, education and clerical work.Teaching in the institutions of general and high education is realized according to the equal number
S V Nikolaenko
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Evaluating Collaborative Learning Processes

open access: yes, 2002
Understanding and analyzing collaborative learning processes require a fine-grained sequential analysis of the group interaction in the context of learning goals. Several researchers in the area of cooperative work take as a success criterion the quality of the group outcome.
César A. Collazos 0001   +3 more
openaire   +3 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Designing professional learning [PDF]

open access: yes, 2014
The Designing Professional Learning report provides a snapshot of the key elements involved in creating effective and engaging professional learning in a globally dispersed market.
Learning Forward
core  

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