Results 71 to 80 of about 1,093,151 (324)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

A Multi-Perspective Learning to Rank Approach to Support Children's Information Seeking in the Classroom [PDF]

open access: green, 2023
Garrett Allen   +4 more
openalex   +1 more source

Learning to Rank Based on Subsequences [PDF]

open access: yes2015 IEEE International Conference on Computer Vision (ICCV), 2015
We present a supervised learning to rank algorithm that effectively orders images by exploiting the structure in image sequences. Most often in the supervised learning to rank literature, ranking is approached either by analysing pairs of images or by optimizing a list-wise surrogate loss function on full sequences.
Fernando, Basura   +3 more
openaire   +1 more source

Regression and Learning to Rank Aggregation for User Engagement Evaluation

open access: yes, 2014
User engagement refers to the amount of interaction an instance (e.g., tweet, news, and forum post) achieves. Ranking the items in social media websites based on the amount of user participation in them, can be used in different applications, such as ...
Moradi, Pooya   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Mask Optimization for Image Inpainting

open access: yesIEEE Access, 2018
This paper proposes a novel approach to image inpainting that optimizes the shape of masked regions given by users. In image inpainting, which removes and restores unwanted regions in images, users draw masks to specify the regions. However, it is widely
Mariko Isogawa   +4 more
doaj   +1 more source

Learning to Rank [PDF]

open access: yesProceedings of the 2015 ACM SIGMETRICS International Conference on Measurement and Modeling of Computer Systems, 2015
Algorithms for learning to rank Web documents, display ads, or other types of items constitute a fundamental component of search engines and more generally of online services. In such systems, when a user makes a request or visits a web page, an ordered list of items (e.g. documents or ads) is displayed; the user scans this list in order, and clicks on
Combes, Richard   +3 more
openaire   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

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