Results 51 to 60 of about 419,205 (270)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Using Maximum Likelihood Method to Estimate Parameters of the Linear Regression T Truncated Model

NTU Journal of Pure Sciences, 2022
The estimation of the parameters is one of an important issues in the mathematical statistics. The development of estimation methods requires accurate estimation and finds the best estimator for parameters.
Elham Abduklreem Hussain, Ahmad N.S.Al-Shallawi, Haifa Abduljawaad Saied   +2 more
doaj   +1 more source

Least Squares Solutions of the HJB Equation With Neural Network Value-Function Approximators [PDF]

IEEE Transactions on Neural Networks, 2007
In this paper, we present an empirical study of iterative least squares minimization of the Hamilton-Jacobi-Bellman (HJB) residual with a neural network (NN) approximation of the value function. Although the nonlinearities in the optimal control problem and NN approximator preclude theoretical guarantees and raise concerns of numerical instabilities ...
Yuval, Tassa, Tom, Erez
openaire   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Derivation Of Moving Least-Squares Approximation Shape Functions And Its Derivatives Using The Exponential Weight Function

Civil Engineering Dimension, 2007
In recent years, meshless methods have gained their popularity, mainly due to the fact that absolutely no elements are required to discretize the problem domain.
Effendy Tanojo
doaj  

Enhancing SPH using moving least-squares and radial basis functions

, 2007
In this paper we consider two sources of enhancement for the meshfree Lagrangian particle method smoothed particle hydrodynamics (SPH) by improving the accuracy of the particle approximation.
Brownlee, R. A., Houston, P., Levesley, J., Rosswog, S.   +3 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Speeding-up the Fitting of the Model Defining the Ribs-bounded Contour

Applied Computer Systems, 2017
The method for analysing transversal plane images from computer tomography scans is considered in the paper. This method allows not only approximating ribs-bounded contour but also evaluating patient rotation around the vertical axis during a scan.
Bilinskas Mykolas J., Dzemyda Gintautas, Sabaliauskas Martynas   +2 more
doaj   +1 more source

Modelling and RBF Control of Low-Limb Swinging Dynamics of a Human–Exoskeleton System

Actuators, 2023
With the increase in the elderly population in China and the growing number of individuals who are unable to walk normally, research on lower limb exoskeletons is becoming increasingly important.
Xinyu Peng, Shujun Zhang, Mengling Cai, Yao Yan   +3 more
doaj   +1 more source