Results 61 to 70 of about 419,205 (270)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Archives of Mechanics, 2023 Plate-like structures in channel flow are commonly found in engineering. This paper reports a theoretical study on the static aeroelastic instability of an inverted cantilevered plate in an inviscid channel flow through the state space. This study begins
P. Li, D. Zhang, J. Cui, H. Yin, Y. Yang
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Slovak Journal of Civil Engineering, 2014 A numerical analysis based on the meshless local Petrov- Galerkin (MLPG) method is proposed for a functionally graded material FGM (FGMfunctionally graded material) beam.
Sátor Ladislav +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Sequential and Adaptive Learning Algorithms for M-Estimation
EURASIP Journal on Advances in Signal Processing, 2008 The M-estimate of a linear observation model has many important engineering applications such as identifying a linear system under non-Gaussian noise.
Guang Deng
doaj +1 more source
On Estimation of Bi‑liner Regression Parameters
Acta Universitatis Lodziensis. Folia Oeconomica, 2017 Two non‑parallel lines will be named as bi‑lines. The relationship between the definition of the bi‑lines function and linear regression functions of the distribution mixture is considered.
Grzegorz Antoni Sitek +1 more
doaj +1 more source
Machine Learning in Least-Squares Monte Carlo Proxy Modeling of Life Insurance Companies
Risks, 2020 Under the Solvency II regime, life insurance companies are asked to derive their solvency capital requirements from the full loss distributions over the coming year.
Anne-Sophie Krah +2 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Least squares surface approximation to scattered data using multiquadric functions
, 1992 This report documents an investigation into some methods for fitting surfaces to scattered data. The form of the fitting function is a multiquadric function with the criteria for the fit being the least mean squared resifual for the data points. The principal problem is the selection of knot points (or base points for the multiquadric basis functions),
Franke, Richard H. +2 more
openaire +3 more sources