Results 81 to 90 of about 419,205 (270)
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Convergence analysis of generalized iteratively reweighted least squares algorithms on convex function spaces [PDF]
The computation of robust regression estimates often relies on minimization of a convex functional on a convex set. In this paper we discuss a general technique for a large class of convex functionals to compute the minimizers iteratively which is ...
Bissantz, Nicolai +3 more
core
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Meshless Local Petrov-Galerkin Method for 3D Steady-State Heat Conduction Problems
Advances in Mechanical Engineering, 2011 The Meshless Local Petrov-Galerkin (MLPG) method is applied for solving the three-dimensional steady state heat conduction problems. This method is a truly meshless approach; also neither the nodal connectivity nor the background mesh is required for ...
M. J. Mahmoodabadi +3 more
doaj +1 more source
Total Least Squares Spline Approximation
Mathematics, 2019 Spline approximation, using both values y i and x i as observations, is of vital importance for engineering geodesy, e.g., for approximation of profiles measured with terrestrial laser scanners, because it enables the consideration of
Frank Neitzel +2 more
doaj +1 more source
Rational-spline approximation with automatic tension adjustment [PDF]
An algorithm for weighted least-squares approximation with rational splines is presented. A rational spline is a cubic function containing a distinct tension parameter for each interval defined by two consecutive knots.
Kerr, P. A., Schiess, J. R.
core +1 more source
Aging and Cancer, EarlyView.This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst +4 more
wiley +1 more source
Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin +2 more
wiley +1 more source
Shape preserving approximation using least squares splines
, 2000 Least squares polynomial splines are an effective tool for data fitting, but they may fail to preserve essential properties of the underlying function, such as monotonicity or convexity.
Beliakov, Gleb
core +1 more source
Kernel Recursive Least Squares Function Approximation in Game Theory Based Control
Procedia Technology, 2016 AbstractA game theoretic aspect in reinforcement learning based controller design with kernel recursive least squares algorithm for value function approximation is proposed in this paper. A kernel recursive least-squares-support vector machine is used to realize a mapping from state, controller's action and disturber's action to Q-value function ...
Shah, Hitesh, Gopal, M.
openaire +1 more source