Results 41 to 50 of about 1,208,864 (273)

Genetic Algorithms: A Tool for Optimization in Econometrics – Basic Concept and an Example for Empirical Applications [PDF]

, 2002
This paper discusses a tool for optimization of econometric models based on genetic algorithms. First, we briefly describe the concept of this optimization technique.
Czarnitzki, Dirk, Doherr, Thorsten
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A model of full bloom starting date of some white Vitis vinifera L. varieties grown in Helvecia

International Journal of Horticultural Science, 2010
Grapevine bloom happens between end of May and the middle of June in Hungary. However, climate change in the past decades and the occurring weather anomalies can modi fy this date to a diverse degree.
M. Ladányi, E. Hlaszny
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The General Least Square Deviation OWA Operator Problem

Mathematics, 2019
A crucial issue in applying the ordered weighted averaging (OWA) operator for decision making is the determination of the associated weights. This paper proposes a general least convex deviation model for OWA operators which attempts to obtain the ...
Dug Hun Hong, Sangheon Han
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Trumpeting M Dwarfs with CONCH-SHELL: a Catalog of Nearby Cool Host-Stars for Habitable ExopLanets and Life [PDF]

, 2014
We present an all-sky catalog of 2970 nearby ($d \lesssim 50$ pc), bright ($J< 9$) M- or late K-type dwarf stars, 86% of which have been confirmed by spectroscopy. This catalog will be useful for searches for Earth-size and possibly Earth-like planets by
A. Buccino, A. W. Mann, Akeson, Aldering, Apps, Asplund, Bacon, Berta, Berta, Bessell, Bochanski, Bochanski, Bohlin, Bohlin, Bond, Bonfils, Boyajian, Brown, Buton, Caffau, Casagrande, Christiansen, Cincunegui, Colón, Costa, Costa, Covey, Cruz, D. James, de Bruijne, Delfosse, Dittmann, Dotter, Dressing, E. Gaidos, E. J. Hilton, Fischer, Fressin, Frith, Fukugita, Gaidos, Gaidos, Gaidos, Gatewood, Gatewood, Gelman, Gizis, Güver, Hadden, Hamuy, Harrington, Henden, Henry, Henry, Horne, Howard, Høg, James, Janson, Jao, Jao, Johnson, Kharchenko, Khrutskaya, Kopparapu, Kopparapu, Lantz, Leggett, Lissauer, Lépine, Lépine, Lépine, M. Ansdell, Mahadevan, Mamajek, Mann, Mann, Mann, Mann, Mann, Marcy, Massey, Massey, McCook, Monet, Moorhead, Myers, Newton, Oke, P. Mauas, Pinsonneault, Quintana, Quirrenbach, R. Petrucci, Rajpurohit, Reid, Ricker, Riedel, Roeser, Rojas-Ayala, Rowe, S. Lépine, Santerne, Scargle, Schiavon, Schlaufman, Schönrich, Skrutskie, Smart, Sotin, Spencer Jones, Stassun, Swift, Tamura, Thibault, Tody, van Altena, van Leeuwen, Weiss, West, Wolfgang, Yuan, Zacharias   +122 more
core   +3 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Linear Regression for Heavy Tails

Risks, 2018
There exist several estimators of the regression line in the simple linear regression: Least Squares, Least Absolute Deviation, Right Median, Theil–Sen, Weighted Balance, and Least Trimmed Squares.
Guus Balkema, Paul Embrechts
doaj   +1 more source

Best Subset Selection via a Modern Optimization Lens [PDF]

, 2015
In the last twenty-five years (1990-2014), algorithmic advances in integer optimization combined with hardware improvements have resulted in an astonishing 200 billion factor speedup in solving Mixed Integer Optimization (MIO) problems.
Bertsimas, Dimitris, King, Angela, Mazumder, Rahul   +2 more
core   +2 more sources