Results 71 to 80 of about 701,217 (307)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Precipitation, Time Series Models, Man-Kendall, Health Winters model, West Azerbaijan Province [PDF]
تحقیقات کاربردی علوم جغرافیاییAssessing and predicting future climate change is of particular importance due to its adverse effects on water resources and the natural environment, as well as its environmental, economic and social effects.
Saeed jahanbakhshasl +3 more
doaj
Black hole initial data by numerical integration of the parabolic-hyperbolic form of the constraints [PDF]
, 2019 The parabolic-hyperbolic form of the constraints is integrated numerically. The applied numerical stencil is $4^{th}$ order accurate (in the spatial directions) while 'time'-integration is made by using the method of lines with a $4^{th}$ order accurate ...
Nakonieczna, Anna +2 more
core +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Robust Determination of Smartphone Heading by Mitigation of Magnetic Anomalies
NavigationWe introduce an algorithm that provides robust three-dimensional orientation of a smartphone for pedestrian indoor localization. The algorithm focuses on integration of the magnetometer and a reformulated observation model such that the influence of ...
Andreas Ettlinger +2 more
doaj +1 more source
LAD Asymptotics under Conditional Heteroskedasticity with Possibly Infinite Error Densities [PDF]
Least absolute deviations (LAD) estimation of linear time-series models is considered under conditional heteroskedasticity and serial correlation. The limit theory of the LAD estimator is obtained without assuming the finite density condition for the ...
Chirok Han +2 more
core
Enhancing the performance of the exact algorithm for implementing the method of least absolute deviations when estimating the parameters of linear regression models [PDF]
, 2017 An algorithm for finding the exact solution of the problem of estimating the parameters of linear regression models by the method of least absolute deviations is described.
Azaryan, A. A. +3 more
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Mogućnosti smanjenja potrošnje energije u vuči vlakova
Promet (Zagreb), 2012 The paper deals with the possibility of energy consumption reduction in train traction. The mathematical model of train traction calculation is furnished and accommodated for purposes of definition of optimum journeys by the criterion of least energy ...
Josip Zavada
doaj +1 more source