Results 191 to 200 of about 11,858,600 (367)

Minimally important difference and responsiveness to change for numerical rating scale of menstrual pain severity: a psychometric study. [PDF]

Front Pain Res (Lausanne)
Chen CX, Wu J, Lee C, Park J, Ahn H, Lin L, Kroenke K.   +6 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Physiological responses of pak choi (Brassica Rapa subsp. Chinensis (L.) Hanelt) to cerium and yttrium in two acidic soils with contrasting textures. [PDF]

Sci Rep
Wu PH, Grillet L, Lin YF, Yeh KC, Hseu ZY.   +4 more
europepmc   +1 more source

Technical Update: Least-Squares Temporal Difference Learning

Machine-mediated learning, 2002
J. Boyan
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A Comparative Evaluation of Marginal Leakage and Shear Bond Strength of Cention N, Resin-Modified Glass Ionomer Cement (RMGIC), and Conventional Glass Ionomer Cement (GIC): An In Vitro Study. [PDF]

Cureus
Singh K, Pradhan D, Tiwari S, Thakur R, Sharma P, Agrawal D, Singh M, Jawalikar D, Kapoor DM, Kodimela JP.   +9 more
europepmc   +1 more source

KEGG pathways (with at least 4 measured proteins) that have at least one significant difference (adjusted p-value (q-value) ≤ 0.05) between treatment groups within visits as determined with ConsensusPathDB.

Diana M. Hendrickx (1507435), Mengyichen Long (22226801), Harm Wopereis (175116), Renate G. van der Molen (11027975), Clara Belzer (596775)   +4 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source