Results 81 to 90 of about 7,117,095 (307)

The Difference in Lemuru Fish Oil Duration of Administration on Connective Tissue Fibroblast Cell Count in Rheumatoid Arthritis Rat Model

open access: yesJournal of Agromedicine and Medical Sciences (AMS), 2017
Rheumatoid arthritis is a joint chronic inflammation process leadingto progressive distruction.Cytokinessecreted from chronic inflammation increases fibroblast cell number that synthesize matrix metalloproteinase.
Asyirah Mujahidah Fillah   +2 more
doaj   +1 more source

Coronary In-Stent Restenosis: Assessment with Corrected Coronary Opacification Difference across Coronary Stents Measured with CT Angiography.

open access: yesRadiology, 2015
PURPOSE To determine whether changes in coronary opacification normalized to the aorta (corrected coronary opacification [CCO]) across stents can help identify in-stent restenosis (ISR) severity with use of invasive coronary angiography as the standard ...
Yang Gao   +10 more
semanticscholar   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

open access: yesFEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli   +10 more
wiley   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

open access: yesFEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen   +2 more
wiley   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

open access: yesFEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter   +8 more
wiley   +1 more source

INVESTIGATION OF DIFFERENCES LEVELS OF PERCEIVED FREEDOM IN LEISURE BETWEEN INDIVIDUALS WHICH ARE PARTICIPATED IN NATURE SPORTS AND MEMBERS OF FITNESS CENTERS [PDF]

open access: yesSportif Bakış Spor ve Eğitim Bilimleri Dergisi, 2018
The purpose of this study is; to identify the difference between the level of freedom perceived by individuals participating in fitness centers and nature sports.
Seydi Karakuş, Fatih Dinç
doaj  

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