Results 161 to 170 of about 4,646,916 (286)

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Acute cholecystitis in high-risk patients: a systematic review, meta-analysis, and practice management guideline from the Eastern Association for the Surgery of Trauma (EAST). [PDF]

Trauma Surg Acute Care Open
Ratnasekera A, Rattan R, Bhattacharya B, Zhang Z, Harris M, Seng SS, Magura C, Butts CA, Rabinowitz J, Kirsch JM, Molavi I, Kaafarani H, Brahmbhatt TS, Cripps MW, Bugaev N, Como JJ.   +15 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

From Naltrexone Induction to Response-Guided Care in Alcohol-Associated Cirrhosis. [PDF]

Liver Int
Mao X, Hu X.
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Universal Health Coverage on $15 per Capita: Somalia's Health Financing Crisis and the Limits of Humanitarian Dependency. [PDF]

Public Health Chall
Abdulle AA, Khalif IA, Abdi AM, Hubow YA, Dahir NA, Adan AM, Bashir SG, Rashid NAS.   +7 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Why do family physicians stay in rural practice? National survey of Canadian primary care clinicians who have stayed or left. [PDF]

Can Fam Physician
Scott I, Gowans M, Eva K.
europepmc   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Health, poverty and employment effects of cutting income replacement benefits for the disabled: a difference-in-differences analysis of the 2017 welfare reforms. [PDF]

J Epidemiol Community Health
Song H, Piroddi R, McHale P, Barr B.
europepmc   +1 more source