Results 101 to 110 of about 241,517 (312)
Xc- System as a Possible Target for ConBr Lectin Interaction in Glioma Cells
NeurogliaStudies have revealed the dependence of glioma cells on iron, making them sensitive to ferroptosis. Ferroptosis can be triggered by inhibition of the xc- system, resulting in redox imbalance and membrane lipid peroxidation.
Vanir Reis Pinto-Junior +9 more
doaj +1 more source
Beyond the fuzzy lock-and-key: spontaneous symmetry shifts and glycan/lectin logic gates
, 2012 Changes in the molecular topology of glycan/lectin interaction may explain observed reaction punctuation driven by experimental gradients in reactant concentration. Adoption of a 'biological renormalization' perspective from statistical physics
Rodrick Wallace
core
, 2016 (A) Antibiofilm activity of the lectin domains of Llp1 and Llp2 of L. rhamnosus GG on S. aureus SH100 and Rosenbach added at zero time point and after 24 hours to the biofilms at a concentration of 200 μg/ml.
Jan Balzarini (161754) +7 more
core +1 more source
Cullin-1/5 degradation requires Gal-lectin-mediated contact with macrophage.
, 2021 (A, B) THP-1 macrophages were stimulated with either Eh (10:1 ratio) alone or with Eh preincubated with 55mM Galactose or Glucose for 10 min at room temperature and the degradation of the cullin-1/5 determined.
Kris Chadee (249039) +4 more
core +1 more source
Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair
Advanced Science, EarlyView.Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li +9 more
wiley +1 more source
Lectin array based strategies for identifying metastasis-associated changes in glycosylation
, 2012 Since 2005, lectin microarray technology has emerged as a relatively simple yet powerful technique for the comprehensive analysis of glycoprotein glycosylation.
Fry, S. +3 more
core +1 more source
Innate immunity in lobsters: Partial purification and characterization of a Panulirus cygnus Anti-A lectin [PDF]
, 2012 A lectin detected in haemolymph from the Australian spiny lobster Panulirus cygnus agglutinated human ABO Group A cells to a higher titre than Group O or B.
Flower, Robert L.P.
core +1 more source
Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles
Advanced Science, EarlyView.Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu +6 more
wiley +1 more source
Renal IGFBP6 Interacts With THBS1 to Drive Renal Cellular Senescence and Fibrosis
Advanced Science, EarlyView.ABSTRACT Epithelial dedifferentiation and myofibroblast activation are critical drivers of chronic kidney disease (CKD) progression. Elevated levels of IGFBP6 have been linked to decreased renal function in CKD patients, but its precise role and underlying mechanisms remain unclear.
Ju‐tao Yu +26 more
wiley +1 more source
Advanced Science, EarlyView.Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao +19 more
wiley +1 more source