Results 111 to 120 of about 3,190,451 (315)

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism [PDF]

, 2018
Table S1. Demographic and clinical features of human subjects used in this study. Figure S1. Aβ deposition in microvessels in AD patients and APPSw/0 mice. Figure S2. Biochemical analysis of Aβ42 aggregates. Figure S3.
Herz, Joachim, Holtzman, David M, Ma, Qingyi, Owens, Nelly Chuqui, Sagare, Abhay P, Verghese, Philip B, Wang, Min, Wu, Yingxi, Zhao, Zhen, Zlokovic, Berislav V   +9 more
core   +3 more sources

Lectins and protein traffic early in the secretory pathway

Biochemical Society Symposia, 2002
Lectins of the early secretory pathway are involved in selective transport of newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER–Golgi intermediate compartment (ERGIC). The most prominent cycling lectin is the mannose-binding type I membrane protein ERGIC-53 (ERGIC protein of 53 kDa), a marker for the ERGIC, which functions ...
Hauri, Hans-Peter, Nufer, Oliver, Breuza, Lionel, Tekaya, Houchaima Ben, Liang, Lu   +4 more
openaire   +3 more sources

Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues

Advanced Science, EarlyView.
Electrical stimulation (ESTIM) enhances vasculature formation in engineered human tissues. In 3D endothelial‐fibroblast constructs, conditioning with ESTIM promotes the formation of dense and highly branched networks that rapidly anastomose with mouse vasculature when implanted in vivo. Vessels formed under ESTIM are importantly functionally perfusable.
Katarzyna A. Grzelak, Ashley D. Westerfield, Vardhman Kumar, Kasturi Chakraborty, Navaneeth Krishna Rajeeva Pandian, Christopher S. Chen, Sangeeta N. Bhatia   +6 more
wiley   +1 more source

The structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket [PDF]

, 2012
P pili are hairlike polymeric structures that mediate binding of uropathogenic Escherichia coli to the surface of the kidney via the PapG adhesin at their tips.
Baga M, Bann JG, Barnhart MM, Dodson KW, Dodson KW, Doublie S, Gong M, Griebling TL, Henderson NS, Hess B, Holmgren A, Hooton TM, Hultgren SJ, Hung DL, Hung DL, Hung DL, Jacob-Dubuisson F, Jones CH, Justice SS, Kabsch W, Knight SD, Kuehn MJ, Kuehn MJ, Leslie A, Martinez JJ, Munera D, Nishiyama M, Painter J, Pellecchia M, Phan G, Remaut H, Remaut H, Roberts JA, Roberts JA, Rose RJ, Sauer FG, Sauer FG, Sauer FG, Saulino ET, Saulino ET, Sheldrick GM, Slonim LN, Striker R, Stromberg N, Verger D, Verger D, Volkan E, Wright KJ, Zavialov AV   +48 more
core   +2 more sources

Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic Modeling of Lectin Pathway Activation Provides Possible Mechanism

Frontiers in Immunology, 2017
Serine proteases (SPs) are typically synthesized as precursors, termed proenzymes or zymogens, and the fully active form is produced via limited proteolysis by another protease or by autoactivation.
G. Oroszlán, Ráhel Dani, A. Szilágyi, P. Závodszky, S. Thiel, P. Gál, J. Dobó   +6 more
semanticscholar   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

E2F1 Suppresses Oxidative Metabolism and Endothelial Differentiation of Bone Marrow Progenitor Cells [PDF]

, 2018
RATIONALE: The majority of current cardiovascular cell therapy trials use bone marrow progenitor cells (BM PCs) and achieve only modest efficacy; the limited potential of these cells to differentiate into endothelial-lineage cells is one of the major ...
Boriboun, Chan, Chandel, Navdeep S., Cheng, Min, Dong, Nian-Guo, Harris, Robert A., Huang, Kai, Liu, Qinghua, Losordo, Douglas W., Qin, Gangjian, Qiu, Hongyu, Shi, Jiawei, Sun, Tianjiao, Tao, Jun, Xu, Shiyue, Yang, Liu, Zhang, Eric, Zhao, Ting C., Zhou, Junlan   +17 more
core   +1 more source

RENAL‐CHIP: Rejection Evaluation via Non‐Invasive Analysis of Circulating Podocytes With Herringbone‐Chip Isolation Platform

Advanced Science, EarlyView.
RENAL‐CHIP converts 1 mL of peripheral blood into a biopsy‐equivalent readout of renal‐allograft fate. By magnetic capture and release of donor‐derived circulating podocytes through a herringbone microfluidic chip, 84% capture, 96% release and single‐cell RNA evidence of rejection‐specific immunity are achieved.
Juan Song, Yilong Liu, Zeyuan Zheng, Ming Zhu, Yuning Zou, Pei Liu, Yue Zheng, Xiyuan Yu, Jianzhong Zheng, Chen Shao, Huimin Zhang, Chaoyong Yang   +11 more
wiley   +1 more source

Mechano-transduction: from molecules to tissues. [PDF]

, 2014
External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.
Dunn, Alexander R, Nelson, W James, Pruitt, Beth L, Weis, William I   +3 more
core   +2 more sources

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source