Results 341 to 350 of about 2,513,226 (377)

The role of ficolins in the lectin pathway of innate immunity

The International Journal of Biochemistry & Cell Biology, 2011
Ficolins are a family of oligomeric proteins consisting of an N-terminal collagen-like domain and a C-terminal globular fibrinogen-like domain. They are novel lectins that employ the fibrinogen-like domain as a functional domain. Ficolins specifically recognize N-acetyl compounds such as N-acetylglucosamine, components of bacterial and fungal cell ...
Misao Matsushita, Teizo Fujita, Yuichi Endo   +2 more
openaire   +3 more sources

Asparaginase inhibits the lectin pathway of complement activation

Molecular Immunology, 2018
Oncological treatment has been associated with an increased risk of infection, most often related to therapy-induced pancytopenia. However, limited research has been conducted on the effect of oncological therapy on the complement system, being part of the non-cellular innate immune system. This became the rationale for an observational clinical study (
Cathelijn E.M. Aarts, Taco W. Kuijpers, Angela M. Kamp, Mischa P. Keizer, M. D. van de Wetering, Diana Wouters, H.N. Caron   +6 more
openaire   +2 more sources

Activation of the lectin pathway in murine lupus nephritis

Molecular Immunology, 2005
In systemic lupus erythematosus (SLE), hypocomplementaemia and complement deposition have been described both in man and in experimental models. A major involvement of the classical pathway of complement activation has been demonstrated in this disease, however relatively little is known about the involvement of the lectin pathway.
Leendert A. Trouw, Jacques M.G.J. Duijs, Anja Roos, Ingeborg M. Bajema, Mohamed R. Daha, Michael Loos, Sven Wagner, Cees van Kooten, Marc A. Seelen   +8 more
openaire   +3 more sources

Association of Lectin Pathway Protein Levels and Genetic Variants Early after Injury with Outcomes after Severe Traumatic Brain Injury: A Prospective Cohort Study.

Journal of Neurotrauma, 2017
The lectin pathway of the complement system has been implicated in secondary ischemic/inflammatory injury after traumatic brain injury (TBI). However, previous experimental studies have yielded conflicting results, and human studies are scarce.
M. Osthoff, B. Walder, C. Delhumeau, M. Trendelenburg, N. Turck   +4 more
semanticscholar   +1 more source

The lectin pathway of complement: Advantage or disadvantage in HIV pathogenesis?

Clinical Immunology, 2014
The pattern recognition molecules of the lectin complement pathway are important components of the innate immune system with known functions in host-virus interactions. This paper summarizes current knowledge of how these intriguing molecules, including mannose-binding lectin (MBL), Ficolin-1, -2 and -3, and collectin-11 (CL-11) may influence HIV ...
Ballegaard, Vibe Cecilie Diederich, Haugaard, Anna Karen, Garred, P, Nielsen, Susanne Dam, Munthe-Fog, L   +4 more
openaire   +4 more sources

The mannan-binding-lectin pathway of the innate immune response

Current Opinion in Immunology, 2001
Dramatic progress has been achieved during the past year in our understanding of how the complement system is activated via the mannan-binding-lectin pathway. Surprising discoveries have changed our concepts of the complexes that are formed upon engagement of mannan-binding lectin with its serine proteases.
Gadjeva, M., Thiel, S., Jensenius, J.C.
openaire   +5 more sources

Relevance of the lectin pathway of complement in rheumatic diseases

2012
Due to its importance both in the clearance of pathogens that contribute as rheumatic etiological agents and in the disposal of apoptotic bodies and potential autoimmune initiators, deficiencies of the components of the lectin pathway of complement have been found to increase susceptibility and modulate the severity of most rheumatic disorders.
Isabela Goeldner, Angelica Beate Winter Boldt, de Messias-Reason Ij   +2 more
openaire   +3 more sources

An Ixodes ricinus Tick Salivary Lectin Pathway Inhibitor Protects Borrelia burgdorferi sensu lato from Human Complement.

Vector Borne and Zoonotic Diseases, 2016
INTRODUCTION We previously identified tick salivary lectin pathway inhibitor (TSLPI) in Ixodes scapularis, a vector for Borrelia burgdorferi sensu stricto (s.s.) in North America. TSLPI is a salivary protein facilitating B. burgdorferi s.s.
A. Wagemakers, J. Coumou, Tim J. Schuijt, Anneke Oei, A. Nijhof, C. van ′t Veer, T. van der Poll, A. Bins, J. Hovius   +8 more
semanticscholar   +1 more source

Significance of glomerular activation of the alternative pathway and lectin pathway in lupus nephritis

Lupus, 2011
The objective of the present study was to elucidate the association between glomerular complement depositions belonging to the alternative (AP) and lectin (LP) pathways, and clinical findings of lupus nephritis (LN). Immunofluorescence (IF) was performed on 17 LN patients using antibodies against factor B, factor H, properdin, mannose-binding lectin ...
Hiroyuki Inoshita, Nobuyuki Sato, Yasuhiko Tomino, Seiji Nagamachi, Satoshi Horikoshi, Hiroyuki Ohi, Misao Matsushita, A Toki, Isao Ohsawa, Masaya Ishii, Gaku Kusaba   +10 more
openaire   +3 more sources

An assay for the mannan-binding lectin pathway of complement activation

Journal of Immunological Methods, 2001
The mannan-binding lectin (MBL) pathway of complement activation has been established as the third pathway of complement activation. MBL is a carbohydrate-binding serum protein, which circulates in complex with serine proteases known as mannan-binding lectin associated serine proteases (MASPs).
Petersen, Steen Vang, Thiel, S, Jensen, L, Steffensen, R, Jensenius, J C   +4 more
openaire   +5 more sources