Results 321 to 330 of about 12,603,366 (384)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Time-Dependent Optothermal Performance Analysis of a Flexible RGB-W LED Light Engine. [PDF]

Micromachines (Basel)
Islam MS, Arik M.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Impact of pharmacist-led educational services in promoting breast cancer awareness. [PDF]

BMC Womens Health
Mehmood N, Khan A, Abbas S, Mushtaq S, Fang Y, Ans M, Fakhar-Ud-Din, Khan GM.   +7 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Driving health transformation: big pharma's innovation labs revolution. [PDF]

Health Res Policy Syst
Peralta G, Sánchez B.
europepmc   +1 more source

Performance analysis and optimization of modulation techniques for underwater optical wireless communication in varied aquatic environments. [PDF]

Sci Rep
Zayed MM, Shokair M.
europepmc   +1 more source

Auto LEDs

III-Vs Review, 2006
openaire   +1 more source

Far-field wireless power transmission module with MEMS-based laser steering for optogenetic applications. [PDF]

iScience
Kim Y, Kim BK, Kim KS.
europepmc   +1 more source

Light-Emitting Diode [LED]-Driven Mechanisms for Postharvest Decay Control and Functional Quality Improvement in Fruits and Vegetables. [PDF]

Foods
Obajuluwa AO, Sivakumar D.
europepmc   +1 more source