Results 91 to 100 of about 73,275 (316)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Large-scale SiO2 photonic crystal for high efficiency GaN LEDs by nanospherical-lens lithography

open access: yes, 2014
Wafer-scale SiO2 photonic crystal (PhC) patterns (SiO2 air-hole PhC, SiO2-pillar PhC) on indium tin oxide (ITO) layer of GaN-based light-emitting diode (LED) are fabricated via novel nanospherical-lens lithography.
Wei TB(魏同波)   +7 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Remote temperature mapping of high-power InGaN/GaN MQW flip-chip design LEDs

open access: yes, 2005
We report on the study of heat 2D-distribution in InGaN LEDs with the stress made on local device overheating and temperature gradients inside the structure.
Zakheіm А. L.   +3 more
core  

AlGaN ultraviolet micro-LEDs [PDF]

open access: yes, 2022
AlGaN-based UV LEDs have proven to have broad applications in many fields including sterilization, disinfection, purification, and phototherapy, but the performance still needs to be further improved.
Gu, Erdan   +6 more
core  

The use of orange-red emitting Ba2Ca(BO3)2:Sm3+ phosphor to improve chromaticity and luminance of conventional white leds

open access: yesJournal of Advanced Engineering and Computation
The characteristics of configuration and illumination of Sm3+ incorporated Ba2Ca(BO3)2 samples produced using the traditional solid-status approach are discussed in this study.
Nguyen Thi Phuong Thao, Hsiao Yi Lee
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Growth and Maturation of Gametophyte in Eisenia bicyclis under Different Light Quality from Light Emitting Diodes(LEDs) [PDF]

open access: yes, 2014
We investigated the effect on growth and maturation of gametophyte in Eisenia bicyclis at 20℃, 12 h light-12 h dark cycle and 50μmol m-2 s―1 using four different light emitting diodes (LEDs) and a fluorescent light . The relative growth rates of the male
Abe, Mahiko   +19 more
core  

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