Results 91 to 100 of about 5,649,672 (258)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Sociologia, peronismo e esquerda na Argentina Sociology, peronism and left in Argentina

open access: yesEstudos de Sociologia, 2007
O trabalho discute, o papel do peronismo e os problemas político-ideológicos que ele coloca para a esquerda Argentina. Busca, também, apresentar os principais elementos para uma análise da esquerda frente ao fenômeno do peronismo. <b> ...
Carlos R. Etulain
doaj  

Dissection of 4L lymph node for left-sided non-small cell lung cancer: a meta-analysis

open access: yesFrontiers in Oncology
BackgroundThe therapeutic efficacy of left lower paratracheal (4L) lymph node dissection in the management of left-sided non-small cell lung cancer (NSCLC) remains an unresolved clinical question.
Chenxi Li   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Influence of Pericardial Fat on Left Ventricular Diastolic Function

open access: yesDiagnostics
Background: Heart failure is a major cause of morbidity and mortality worldwide; left ventricular diastolic dysfunction plays a leading role in this clinical context.
Patrícia Coelho   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Cartografía de las publicaciones periódicas judías de izquierda en Argentina, 1900-1953

open access: yesRevista del Museo de Antropologia, 2008
The strong political and cultural investment in the printed word that took place within the ArgentineJewish cultural world throughout the twentieth century was particularly intense and rich in the arc of theideological left. Thus, based on a lengthy work
Alejandro Dujovne
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Une « ligne rouge » persistante face au populisme et au néolibéralisme : la gauche en Argentine depuis 1945

open access: yesCahiers d’histoire
This article explores the trajectory of the left in Argentina since 1945, with the emergence of peronism, until today. It analyzes different cultures and political identities: socialists, communists, Trotskyists, Maoists and Guevarists, among others.
Hernán Camarero
doaj   +1 more source

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