Results 71 to 80 of about 3,145,881 (286)

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Myocardial bridging on left anterior descending coronary artery evaluated by multidetector computed tomography

, 2004
Myocardial bridging on left anterior descending coronary artery evaluated by multidetector computed ...
AMOROSO G., PANCONI M., GEMIGNANI C., RONDINE P., MARIANI M., FALASCHI F., PETRONIO, ANNA, BATTOLLA L.   +7 more
core   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

An unusual electrocardiographic presentation of acute obstruction of the left anterior descending coronary artery

, 2008
Acute obstruction of the left anterior descending coronary artery is generally presented electrocardiographically as isolated anterior or combined anterior and inferior ST-elevation myocardial infarction.
Aygül, Nazif, Düzenli, Mehmet Akif, Altunkeser, Bülent Behlül, Aydın, Meryern Ülkü   +3 more
core   +1 more source

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

Advanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang, Hongzhao Qi, Yanyan Yang, Feng Wang, Tiantian Han, Yanbei Lei, Xiaolu Li, Zhibin Wang, Hua Qu, Tao Yu, Pin Sun   +10 more
wiley   +1 more source

Left anterior descending artery hyper dominance giving rise to the posterior descending artery: an extremely rare coronary anomaly and its clinical implications

Journal of Community Hospital Internal Medicine Perspectives, 2020
The prevalence of congenital coronary artery anomalies is approximately 1% in the general population. They are a common cause of sudden death in younger persons. The origination of the posterior descending artery (PDA) from left anterior descending (LAD)
Muhammad Shabbir Rawala, Alex Munoz, S. Tahira Shah Naqvi, Mohammad Hassan Pervaiz   +3 more
doaj   +1 more source

Habitat‐Specific Design Strategies for Untethered Soft Robots

Advanced Science, EarlyView.
Habitat shapes the design of untethered soft robots. Across land, water, air, and living tissues, environmental constraints govern viable combinations of compliant structures, actuation mechanisms, and energy delivery. This review connects these constraints with robotic performance and identifies design principles for advancing adaptable, durable, and ...
Siyang Li, Zhikun Miao, Tuck‐Whye Wong, Tiefeng Li   +3 more
wiley   +1 more source

Ischemic Postconditioning Protects Aged Myocardium Against Ischemia/Reperfusion Injury by Regulating Mitochondrial Dynamics via piR‐4913

Advanced Science, EarlyView.
A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Xiangyu Zhao, Yanchun Li, Nan Li, Juan Zhang, Xiaolong Ma, Fei Yang, Ruihan Long, Yining Tian, Yichen Wang, Shengchao Ma, Huiping Zhang, Yideng Jiang   +11 more
wiley   +1 more source

Left Anterior Descending Coronary Artery Aneurysm, Rare Case [PDF]

, 2013
Sol ön inen koroner arter anevrizması nadir gözlenen bir koroner anomalidir. Bu yazıda efor anjinası sebebiyle koroner anjiyografi yapılan ve sol ön inen koroner arter anevrizması saptanan 72 yaşında erkek olguyu sunmayı amaçladık.Left anterior ...
Gür, Özcan, Özkaramanlı Gür, Demet, Gürkan, Selami, Arar, Makbule Cavidan, Alpsoy, Şeref   +4 more
core   +1 more source