Results 171 to 180 of about 2,057,922 (254)

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou   +5 more
wiley   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

open access: yesThe FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon   +4 more
wiley   +1 more source

Characterization of AF Recurrence and Substrate Health by Electrographic Flow (EGF) Consistency in EGF Mapping

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Electrographic flow (EGF) mapping is an FDA 510(k)‐cleared method for visualizing atrial activation wavefronts in atrial fibrillation (AF). Its clinical efficacy in detecting AF sources was demonstrated in the FLOW‐AF randomized controlled trial, and the underlying machine learning strategy used to develop and refine EGF source ...
Steven Castellano   +9 more
wiley   +1 more source

Time‐Dependent Diagnostic Yield and Therapeutic Impact of Implantable Loop Recorders, Brugada Syndrome as the Exception

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
Diagnostic yield and therapeutic impact varied substantially according to the indication for implantation. Actionable diagnoses were concentrated in the early follow‐up period for syncope and palpitations, whereas late atrial fibrillation detection after cryptogenic stroke could still modify antithrombotic management. In contrast, patients with Brugada
Luigi Cocchiara   +17 more
wiley   +1 more source

Anatomical Determinants of the Left Atrial Electrograms: Wall Thickness and Myocardial Fat Infiltration

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction Electrogram peak‐to‐peak voltage depends on atrial wall structure and mapping configuration. We evaluated the relationship between computed tomography–derived atrial wall thickness, intramyocardial fat, myocardial muscle thickness, and electrogram voltage obtained with omnipolar, bipolar, and unipolar mapping.
Cecilia Granata   +21 more
wiley   +1 more source

Learning Curve of Pentaspline Pulsed‐Field Ablation With Posterior Wall Isolation for Persistent Atrial Fibrillation

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Pentaspline pulsed‐field ablation (PFA) has emerged as a novel modality for pulmonary vein isolation (PVI) and posterior wall isolation (PWI) in persistent atrial fibrillation (AF). However, the learning curve associated with combined PVI + PWI and the contribution of anatomical factors to acute lesion completeness remain ...
Atsuhiko Yagishita   +5 more
wiley   +1 more source

Impact of Ganglionated Plexus Ablation on Early Recurrence After Thoracoscopic Atrial Fibrillation Ablation: A Post Hoc Analysis of the AFACT Study

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
Adjunctive ganglionated plexus (GP) ablation did not reduce early AF recurrence after thoracoscopic AF ablation but was associated with a later first recurrence. In the GP‐ablation group, early recurrence was associated with late recurrence; this exploratory finding is compatible with, but does not establish, a greater contribution of pre‐existing ...
Zhenyu Dong   +11 more
wiley   +1 more source

Pulmonary Vein Isolation Alone Versus Adjunctive Ablation for Paroxysmal Atrial Fibrillation

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
Clinical Outcomes of Pulmonary Vein Isolation Alone Versus Additional Lesion Sets in Paroxysmal Atrial Fibrillation ABSTRACT Background Pulmonary vein isolation (PVI) is the standard ablation strategy for paroxysmal atrial fibrillation (PAF). Despite guideline recommendations favoring PVI alone in PAF, some operators routinely perform extra pulmonary ...
Michel Abou Khalil   +17 more
wiley   +1 more source

Temporal Association Between Intrathoracic Impedance and Tachyarrhythmia Occurrence

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
A decrease in intrathoracic impedance is temporally associated with subsequent AF occurrence and, at the episode level, with a shorter time to VT. These findings suggest that daily intrathoracic impedance may provide information on short‐term changes preceding tachyarrhythmia occurrence.
Monika Butkuvienė   +5 more
wiley   +1 more source

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