Results 61 to 70 of about 1,995,336 (294)

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Longitudinal Echocardiographic Surveillance of Aortic Dilation in a Phenotype‐Enriched Turner Syndrome Cohort

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Turner syndrome (TS) is associated with thoracic aortopathy and increased risk for aortic dissection, yet the natural history of aortic dilation is not well understood. We performed a retrospective longitudinal study of individuals with TS who participated in the TS Society of the United States Healthy Heart Project between 2003 and 2023 ...
Dylan Doerner, Matthew R. Johnson, Sara Mansoorshahi, Rakesh Kathiresan, Katelyn Abel, Jonathan G. You, Emilio Quezada, Siddharth K. Prakash   +7 more
wiley   +1 more source

Left Atrial Appendage Occlusion Guided Only by Transesophageal Echocardiography

Cardiology Research and Practice, 2019
Aims. To investigate a new method of left atrial appendage occlusion without fluoroscopy. Methods and Results. We performed left atrial appendage occlusion for 14 patients with atrial fibrillation in our hospital. All of the surgeries were completed in a
Jinlong Zhao, Feng Li, Yueli Zhang, Zhongyun Zhuang, Man Wang, Liang Fu, Yinkai Ni, Zhexin Lu, Zonghui Chen, Cheng Zhang   +9 more
doaj   +1 more source

Left atrial appendage closure with the Amplatzer cardiac plug in patients with atrial fibrillation

, 2012
Percutaneous left atrial appendage closure (LAAC) has emerged as an alternative to oral anticoagulation (OA) for prevention of thromboembolic stroke in patients with non-valvular atrial fibrillation (NVAF)
Peter M. Wenaweser, Wenaweser, Peter M, Windecker, Stephan, Michael Schmid, Bernhard Meier, Wenaweser,Peter M., Guérios,Ênio Eduardo, Ênio Eduardo Guérios, Khattab,Ahmed A., Gloekler,Steffen, Stephan Windecker, Schmid,Michael, Steffen Gloekler, Meier,Bernhard, Ahmed A. Khattab, Windecker,Stephan, Guérios, Enio Eduardo, Gloekler, Steffen, Khattab, Ahmed A, Schmid, Michael, Meier, Bernhard   +20 more
core   +1 more source

A Novel Splice Variant in ERGIC1 Causes Arthrogryposis Multiplex Congenita—Characterization Using Urine‐Derived Cells

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis multiplex congenita (AMC) is defined as the presence of joint contractures affecting at least two body regions at birth. Three different ERGIC1 variants have been reported in individuals with AMC. Here, we report on a 16‐year‐old male with a homozygous ERGIC1 c.250+1G>A variant that was classified as a variant of uncertain ...
Lauren Kerr, Paul McKay, Juliana Marulanda, Zenghui Wu, Reggie Hamdy, Sena Tavukcu, Noémi Dahan‐Oliel, Frank Rauch   +7 more
wiley   +1 more source

Two‐Year Outcomes With a Next‐Generation Left Atrial Appendage Device: Final Results of the PINNACLE FLX Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The PINNACLE FLX (Protection Against Embolism for Non‐valvular AF [Atrial Fibrillation] Patients: Investigational Device Evaluation of the Watchman FLX LAA [Left Atrial Appendage] Closure Technology) trial evaluated the safety and efficacy of ...
Shephal K. Doshi, Saibal Kar, Ashish Sadhu, Rodney Horton, Jose Osorio, Christopher Ellis, James Stone, Manish Shah, Srinivas R. Dukkipati, Stuart Adler, Devi G. Nair, Jamie Kim, Oussama Wazni, Matthew J. Price, David R. Holmes, Robert Shipley, Thomas Christen, Dominic J. Allocco, Vivek Y. Reddy   +18 more
doaj   +1 more source

Beyond wound sealing: A dual‐functional adhesive nanofiber membrane promoting coagulation and osteogenesis in extraction sites

BMEMat, EarlyView.
Inspired by the suction mechanics of octopus suckers, a dual‐layer nanofiber membrane integrates antibacterial protection, strong wet adhesion, and osteogenic support, offering a bioinspired strategy for effective hemostasis and alveolar bone preservation.
Huijing Ma, Liheng Gao, Hao Liang, Wentao Jiang, Junyi Wang, Jiajia Wang, Shuhan Duan, Lingxi Meng, Adilijiang Yimiti, Wenjie Zhang   +9 more
wiley   +1 more source

Device-Assisted Left Atrial Appendage Exclusion: From Basic Sciences to Clinical Applications

Journal of Cardiovascular Development and Disease
Device-assisted left atrial appendage exclusion plays a crucial role in the prevention of fatal ischemic complications in patients with atrial fibrillation and contraindications to anticoagulation treatment. Various devices with different safety profiles
Julia Izabela Karpierz, Michał Piotrowski, Krzysztof Bartuś, Radosław Chmiel, Katarzyna Wijatkowska, Artur Słomka   +5 more
doaj   +1 more source

Different Techniques of Surgical Left Atrial Appendage Closure and Their Efficacy: A Systematic Review

Reviews in Cardiovascular Medicine, 2023
Background: Atrial fibrillation has been identified as an independent risk factor for thromboembolic events. Since 1948 different surgical techniques have described the feasibility and the rationale of left atrial surgical appendage closure.
Mizar D'Abramo, Silvia Romiti, Sara Saltarocchi, Wael Saade, Flaminia Spunticchia, Noemi Bruno, Mariangela Peruzzi, Fabio Miraldi, Giacomo Frati, Ernesto Greco, Francesco Macrina, Paolo De Orchi, Antonino G. M. Marullo   +12 more
doaj   +1 more source

Left Atrial Appendage Exclusion for Atrial Fibrillation [PDF]

Heart Failure Clinics, 2014
Percutaneous left atrial appendage (LAA) closure is being increasingly used as a treatment strategy to prevent stroke in patients with atrial fibrillation (AF) who have contraindications to anticoagulants. Several approaches and devices have been developed in the last few years, each with their own unique set of advantages and disadvantages.
Faisal F, Syed, Christopher V, DeSimone, Paul A, Friedman, Samuel J, Asirvatham   +3 more
openaire   +3 more sources