Results 181 to 190 of about 7,583,455 (297)

Assembly and Maintenance of Myofibrils in the Heart

Cytoskeleton, EarlyView.
ABSTRACT The assembly of actin and myosin to the paracrystalline arrangement of myofibrils in striated muscle, that is, heart and skeletal, has puzzled many a cell biologist. Different models, based on cultured cardiomyocytes, were proposed for the last 30 years to explain the sequence of events.
Elisabeth Ehler
wiley   +1 more source

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

Clinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco   +5 more
wiley   +1 more source

Evaluation of the relationship between mitral valve morphology and left atrial function in severe mitral regurgitation. [PDF]

Quant Imaging Med Surg
Wang L, Xie W, Luo X, Li X, Qian X, Zhao C, Zhou Y.   +6 more
europepmc   +1 more source

Impaired left atrial function increases the risk of incident atrial fibrillation and heart failure with preserved ejection fraction in hypertensive patients. [PDF]

BMC Cardiovasc Disord
Ai Y, Long S, He L, Li J, Xu W, Yue J, Luo J, Yang J, Shi X.   +8 more
europepmc   +1 more source

Enhancing Evidence Generation by Linking Randomized Clinical Trials to Real‐World Data: The INVESTED‐Medicare Linkage Study

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐based INVESTED trial (2016–2019) with Medicare fee‐for‐service claims (2012 ...
Hanseul Cho, HoJin Shin, Mehdi Najafzadeh, Brian Claggett, Janinne Ortega‐Montiel, Jun Liu, Julie M. Paik, Narlina F. Lalani, Marie C. Bradley, John Concato, Scott D. Solomon, Orly Vardeny, Elisabetta Patorno   +12 more
wiley   +1 more source

Prognostic implications of impaired three-dimensional left atrial function and stiffness in primary mitral regurgitation. [PDF]

Cardiovasc Ultrasound
Berg-Hansen CE, Sindre RB, Grymyr LMD, Aas CL, Urheim S, Hung J, Cramariuc D.   +6 more
europepmc   +1 more source

GW26-e3524 Value of the left atrial function index for assessing left atrial function in patients with atrial fibrillation

Journal of the American College of Cardiology, 2015
Li, Tianliang, Li, Bao, Duan, Chenliang, Hu, Xinling, Zhang, Xiaoli   +4 more
openaire   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Zebrafish inversin mutants develop scoliosis in the absence of laterality defects

Developmental Dynamics, EarlyView.
Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick, Lorraine Eley, Deborah J. Henderson, Bill Chaudhry   +3 more
wiley   +1 more source

Left atrial function in class III obesity: a pilot study using two-dimensional speckle tracking echocardiography. [PDF]

BMC Cardiovasc Disord
Tudík P, Jurica J, Péč MJ, Focko B, Miertová Z, Miert A, Kubíková L, Nagy N, Lecký P, Ságová I, Bolek T, Vachalcová MB, Mokáň M, Samoš M.   +13 more
europepmc   +1 more source