Results 91 to 100 of about 4,173,619 (259)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Formation of Saturn's ring spokes by lightning-induced electron beams [PDF]

, 2006
Spokes are near-linear markings sometimes visible on Saturn's rings. They are widely accepted as being electrostatically-levitated sheets of similar to 0.6 micron-radius charged grains.
Lagg, A, Roussos, E, Mitchell, DG, Krüger, H., Jones, G., Arridge, C., McAndrews, HJ, Krupp, N., Krupp, N, Dougherty, MK, Jones, G. H., Woch, J, Arridge, C. S., Krimigis, S., Kruger, H, Ip, WH, Franz, M, Mitchell, D., Woch, J., Ip, W., McAndrews, H. J., McAndrews, H., Mitchell, D. G., Krimigis, S. M., Arridge, CS, Lagg, A., Fränz, M., Dougherty, M. K., Dougherty, M., Ip, W.-H., Jones, GH, Krimigis, SM, Roussos, E.   +32 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

survey effect of illuminance source on alertness in a laboratory design

Salāmat-i kār-i Īrān, 2019
Background and aims: Workplaces with poor lighting conditions often created occupational accidents or illness. This occurs because light cause visual and nonvisual effects on numerous physiological variables, such as the human sleep-wake cycle and ...
behzad fouladi, abbas mohammadi, ali rastin, kabize ahmadi, faramarz ghargozlu   +4 more
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Weakly and strongly regular near-rings

, 2005
In this paper, we prove some basic properties of left weakly regular near-rings. We give an affirmative answer to the question whether a left weakly regular near-ring with left unity and satisfying the IFP is also right weakly regular.
N. J. Groenewald, N. Argac, Argac, N, Groenewald, NJ   +3 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source