Results 121 to 130 of about 2,679,339 (286)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Retro-aortic left renal vein as an uncommon cause of left sided varicocele and haematuria

, 2020
Retro-aortic left renal vein [RLRV] is a congenital anomaly characterised by a left renal vein passing posterior to abdominal aorta. It has been suggested that RLRV may cause varicocele and haematuria.
Norhasiza, Mat Jusoh, Hun, Cheah Wai, Yasrul Izad, Abu Bakar   +2 more
core   +1 more source

Nutcracker syndrome due to left renal vein compression by an aberrant right renal artery

, 2007
Classic nutcracker syndrome is caused by left renal vein compression between the superior mesenteric artery and aorta, leading to retrograde venous hypertension associated with such urinary abnormalities as hematuria or proteinuria. We describe a case of
Tsetis D, Patti MT, Calcara G, MIDIRI, Massimo, Coppolino F, Granata A., Basile A, Figuera M   +7 more
core   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Leiomyosarcoma of the Renal Vein That Enlarged Laterally While Preserving the Structure of the Renal Vein Lumen

IJU Case Reports
Introduction Primary renal vein leiomyosarcoma is an extremely rare disease and the tumor often infiltrates the vessel wall. We report a case of primary renal vein leiomyosarcoma that enlarged while preserving the structure of the renal vein lumen.
Naoki Tashiro, Yume Sakaki, Akito Fujinaga, Takahiro Nagai, Chie Onizuka, Shoichiro Mukai, Yoshiko Umekita, Yuichiro Sato, Toshiyuki Kamoto, Atsuro Sawada   +9 more
doaj   +1 more source

Circumaortic left renal vein and double right renal vein: a case report

, 2015
Venous malformation of the kidney is not uncommon. However, bilateral variation of renal veins is of rare occurrence and is clinically significant. In the present case, left renal vein divided into left pre and retro-aortic renal veins which passed in ...
Nurul Nadiah Zainal Abidin
core  

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Retroaortic left renal vein and inflammatory abdominal aortic aneurysm

, 2010
The aim of this study was to report successful surgical management of an inflammatory abdominal aortic aneurysm associated with a retroaortic left renal vein. The patient, a 78-year-old man, presented with diffuse abdominal pain, fever, and constipation.
BAJARDI, Guido, Vitale, G, BRACALE, Umberto Marcello, Mirabella, D   +3 more
core   +1 more source