Results 41 to 50 of about 444,481 (297)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An HPC-Based Approach to Study Living System Computational Model Parameter Dependency [PDF]

, 2015
High performance computing (HPC) allows one to run in parallel large amount of independent numerical experiments for computationally intensive simulations of a complex system.
Byordov, D., Ushenin, K.
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Automatic segmentation of the left ventricle cavity and myocardium in MRI data [PDF]

, 2006
A novel approach for the automatic segmentation has been developed to extract the epi-cardium and endo-cardium boundaries of the left ventricle (lv) of the heart. The developed segmentation scheme takes multi-slice and multi-phase magnetic resonance (MR)
Azhari, Bland, Canny, Cerqueira, Chakraborty, Cootes, Delibasis, Duda, Gerard, Gerig, Hamarneh, Hartigan, Kass, Lelieveldt, Ligier, Ligier, Lynch, M. Lynch, Malladi, Malladi, McCann, McInerney, McInerney, Mitchell, Montagnat, Myerson, O. Ghita, Osher, P.F. Whelan, Perona, Rogers, Sanchez-Ortiz, Sanchez-Ortiz, Schalla, Sethian, Spreeuwers, Späth, Staib, Suri, Suri, Urschler, van der Geest, Waiter   +42 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Giant cardiac tumor resection combined with left ventricular reconstruction

Journal of Cardiothoracic Surgery
Reports of large tumors of the left ventricle are rare. In this instance, we present a situation where a 57-year-old woman underwent surgical intervention for a sizable mass in her left ventricle.
Ganyi Chen, Hong Ran, Cunhua Su, Xin Chen   +3 more
doaj   +1 more source

Double-outlet left ventricle. Echocardiographic diagnosis

Arquivos Brasileiros de Cardiologia, 2001
This is a case report of a double-outlet left ventricle associated with tricuspid atresia and hypoplasia of the right ventricle, diagnosed during echocardiography with color-flow imaging, in a three-month-old child who presented with fatigue and cyanosis.
Lilian Maria Lopes, Paula Iamac Nomura de Rangel, Angela Maria Broglio Soraggi, Beatriz Helena Sanches Furlanetto, Gláucio Furlanetto   +4 more
doaj   +1 more source

Acute exhaustive aerobic exercise training impair cardiomyocyte function and calcium handling in Sprague-Dawley rats. [PDF]

PLoS ONE, 2017
INTRODUCTION:Recent data from long-distance endurance participants suggest that cardiac function is impaired after completion. Existing data further indicate that right ventricular function is more affected than left ventricular function.
Kristine Ljones, Henning Ofstad Ness, Karin Solvang-Garten, Svein Erik Gaustad, Morten Andre Høydal   +4 more
doaj   +1 more source

Multi-Planar Deep Segmentation Networks for Cardiac Substructures from MRI and CT

, 2017
Non-invasive detection of cardiovascular disorders from radiology scans requires quantitative image analysis of the heart and its substructures. There are well-established measurements that radiologists use for diseases assessment such as ejection ...
Bagci, Ulas, Burt, Jeremy, Mortazi, Aliasghar   +2 more
core   +1 more source