Results 191 to 200 of about 2,559,660 (290)

Left ventricular longitudinal function and the hyperkinetic profile: an old echo world to rediscover? [PDF]

Crit Care
Gasca-Aldama JC, López-Rodríguez KH, Marché-Fernández OA, Carrasco-Flores MA, Morales-Ferrer JÁ, Vidals-Sánchez M, Gonzáles-Escudero EA, Juárez-León JE, Monares-Zepeda E, Arzate-Ramírez A.   +9 more
europepmc   +1 more source

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

Atrial Septostomy and Left Ventricular Venting During Peripheral VA-ECMO. [PDF]

JACC Adv
Kapoor AB, Stouffer J, Sarma D, Nayak N, Visrodia P, Petree B, Adjei E, Dereshgi AT, Hollis EN, O'Leary J, Alvis B, Williams A, Bacchetta M, Rali AS.   +13 more
europepmc   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Machine Learning-Based Classification of Right and Left Ventricular Outflow Tract Premature Ventricular Contractions. [PDF]

Ann Noninvasive Electrocardiol
Botis M, Tsiachris D, Botis GG, Koumpanakis A, Bartsioka LI, Doundoulakis I, Kordalis A, Antoniou CK, Karanikola AE, Matsopoulos GK, Tsioufis K.   +10 more
europepmc   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Case Report: Left ventricular pseudoaneurysm presenting with ventricular tachycardia. [PDF]

Front Cardiovasc Med
Polat E, Arslan M, Çorbacıoğlu Y, Khalousi A, Önder R, Güngör C.   +5 more
europepmc   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Preoperative Left Ventricular Thrombus and Midterm Outcomes Following Left Ventricular Assist Device Support. [PDF]

J Clin Med
Kahraman U, Dacik B, Karaca S, Daylan A, Ertugay S, Oguz E, Nalbantgil S, Engin C, Ozbaran M, Yagdi T.   +9 more
europepmc   +1 more source