Results 101 to 110 of about 233,338 (314)

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

Left atrial membrane, left ventricular dysfunction, and mitral regurgitation in an adult [PDF]

, 2005
Abdulaziz Alkhulaifi, O Altamimi, C S Carr   +2 more
openalex   +1 more source

Prognostic implications of left ventricular diastolic dysfunction in moderate aortic stenosis [PDF]

, 2022
Jan Stassen, See Hooi Ewe, Steele C. Butcher, Mohammed Amanullah, Bart Mertens, Kensuke Hirasawa, Gurpreet K. Singh, Kenny Yoong Kong Sin, Zee Pin Ding, Stephan Milhorini Pio, Ching‐Hui Sia, Nicholas Chew, William Kong, Kian Keong Poh, David J. Cohen, Philippe Généreux, Martin B. Leon, Nina Ajmone Marsan, Victoria Delgado, Jeroen J. Bax   +19 more
openalex   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

SEVERE POSTDUCTAL COARCTATION OF AORTA PRESENTING LIKE IDIOPATHIC DILATED CARDIOMYOPATHY

Gomal Journal of Medical Sciences, 2017
Left ventricular systolic dysfunction in childhood can be due to many causes. It may be because of sequel of myocarditis, metabolic causes, storage disorder, congenital heart disease or idiopathic dilated cardiomyopathy.
Sandip Ghosh, Biswajit Majumder, Viral Tandel, Praveen Shukla, Prokash Chandra Bagchi   +4 more
doaj  

Recovery of left ventricular dysfunction after ST-elevation myocardial infarction: comparison between 2D Doppler echocardiography and contrast enhanced cardiac MRI [PDF]

, 2011
Daniel Couri, Matthew W. Martinez, Imran S. Syed, Scott R. Harris, James F. Glockner, Phillip A Aroaz, Abhiram Prasad, Charanjit S. Rihal, Jae K. Oh   +8 more
openalex   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Fe‐based magnetic nanocubes conjugated with TRPV1 antibodies (FeNCs‐TRPV1) are developed for the specific targeting of TRPV1 channels. Intraspinally injected FeNCs‐TRPV1 induces TRPV1 desensitization in rats exposed to repetitive and transient ACMF.
Xueying Cheng, Shuangyu Liu, Yu Zhang, Kang Peng, Muge Qile, Chao Wu, Mengyun Dou, Liu Liu, Na Yang, Rui Liu, Guiyang Zhang, Liangping Ni, Gaolin Liang, Fang Yang, Ye Zhang, Shufang He   +15 more
wiley   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source