Results 131 to 140 of about 2,797,109 (304)

SEVERE POSTDUCTAL COARCTATION OF AORTA PRESENTING LIKE IDIOPATHIC DILATED CARDIOMYOPATHY

Gomal Journal of Medical Sciences, 2017
Left ventricular systolic dysfunction in childhood can be due to many causes. It may be because of sequel of myocarditis, metabolic causes, storage disorder, congenital heart disease or idiopathic dilated cardiomyopathy.
Sandip Ghosh, Biswajit Majumder, Viral Tandel, Praveen Shukla, Prokash Chandra Bagchi   +4 more
doaj  

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Depressive Symptoms and Left Ventricular Diastolic Dysfunction Among Men and Women with HIV [PDF]

Background and Aim: The prevalence of depressive symptoms and major depressive disorder is high among adults living with HIV. Depressive symptoms are associated with increased cardiovascular disease risk.
Alcaide, Maria L., Margaret A. Fischl, Jones, Deborah L., Adaora A. Adimora, Spence, Amanda Blair, Rodriguez, Violeta J, McKay, Heather, Joao A. C. Lima, Carlos J. Rodriguez, Wingood, Gina, Weinstein, Andrea M., Post, Wendy S., Martinez, Claudia, Kizer, Jorge R, Fischl, Margaret A., Wendy S. Post, Kozlova, Sofia, Violeta J. Rodriguez, Lima, Joao AC, Post, Wendy S, Katherine C. Wu, Rodriguez, Violeta J., Amanda Blair Spence, Jones, Deborah L, Konkle-Parker, Deborah, Yasmeen Golzar, Wu, Katherine C., Lima, Joao A. C., Haw, Nel Jason, Wise, Jenni M., Lazar, Jason, Jason Lazar, Wise, Jenni M, Wu, Katherine C, Fischl, Margaret A, Budoff, Matthew, Gina Wingood, Golzar, Yasmeen, Frank J Palella, Alcaide, Maria L, Sofia Kozlova, Plankey, Michael, Rodriguez, Carlos J, Claudia Martinez, Jorge R. Kizer, Michael Plankey, Deborah L. Jones, Maria L. Alcaide, Rodriguez, Carlos J., Deborah Konkle-Parker, Adimora, Adaora A, Palella, Frank J, Nel Jason Haw, Andrea M. Weinstein, Jenni M. Wise, Matthew Budoff, Heather McKay, Weinstein, Andrea M, Kizer, Jorge R., Adimora, Adaora A.   +59 more
core   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Prevalence of cardiac dysfunction and longitudinal changes in cardiac function after breast cancer treatment with chemotherapy with/without radiation therapy compared with controls

Breast
Introduction: Breast cancer survivors are known to have a higher prevalence of mild systolic cardiac dysfunction compared to the general population, due to the effects of chemotherapy with/without radiation therapy.
L.T. van der Wal, S.W.M.C. Maass, M.R. de Boer, M.H. Blanker, A.P.G. Crijns, J.A. Gietema, P. van der Meer, G.H. de Bock, D. Brandenbarg   +8 more
doaj   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

The Content of Vasodilation Factors in Blood Serum at Different Levels of Systolic- Diastolic Dysfunction of Left Ventricular with Stable Stenocardia Complicated by Heart Failure

, 2017
Introduction. Congestive heart failure (CHF) is still the most topical medical­and­social problem all around the world. It is the most common and life­threatening disease of the cardiovascular system, resulting in permanent disability, leads to permanent
Muzyka N., Denesyuk V.
core   +1 more source

Alkylating Agent–Induced FANCL Impairment Damages Pulmonary Arterial, Venous, and Microvascular Endothelial Cells and Predisposes to PAH/PVOD

Advanced Science, EarlyView.
This study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.
Shiyun Liu, Yufei Sun, Xinlei Wu, Haixia Chen, Shaocong Mo, Zichong Li, Yiwei Gong, Xiaoqian Shan, Yuanqi Li, Yaru Guan, Junqi Zhu, Han Yan, Min Du, Feng Wei, Peixin Ou, Ziyi Wang, Chenting Zhang, Lei Xu, Wenju Lu, Jian Wang, Kai Yang   +20 more
wiley   +1 more source

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source