Results 101 to 110 of about 398,963 (376)

A novel quantitative indicator of the left ventricular contraction based on volume changes of the left ventricular myocardial segments [PDF]

open access: yesarXiv, 2018
Ejection fraction (EF) is commonly measured by echocardiography, by dividing the volume ejected by the heart (stroke volume) by the volume of the filled heart (end-diastolic volume). Utilizing volume changes of left myocardial segments per a cardiac cycle, physical laws and mathematical equations specific echocardiographic data, this paper serves to ...
arxiv  

Association of circulating ceramides with cardiac structure and function in the community: The Framingham Heart Study [PDF]

open access: yes, 2019
Background A higher circulating plasma ceramide ratio (C16:0/C24:0) is associated with an increased risk of heart failure, even after accounting for standard risk factors including lipid markers. However, the pathobiological mechanisms that underlie this
Cheng, Susan   +7 more
core   +1 more source

Use of a regional wall motion score to enhance risk stratification of patients receiving an implantable cardioverter-defibrillator [PDF]

open access: yes, 1993
Objectives. We postulated that preoperative assessment of both regional wall motion and left ventricular ejection fraction would serve as an accurate prognostic indicator of long-term cardiac mortality and functional outcome in patients treated with an ...
Barber, Michael J.   +6 more
core   +1 more source

P21‐Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy

open access: yesAdvanced Science, EarlyView.
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li   +21 more
wiley   +1 more source

Comparison of left ventricular ejection fraction values obtained using invasive contrast left ventriculography, two-dimensional echocardiography, and gated single-photon emission computed tomography

open access: yesSAGE Open Medicine, 2016
Objectives: Left ventricular ejection fraction can be measured by a variety of invasive and non-invasive cardiac techniques. This study assesses the relation of three diagnostic modalities to each other in the measurement of left ventricular ejection ...
Nadish Garg   +5 more
doaj   +1 more source

Cardiac function in women receiving dual anti-Her2 antibodies (trastuzumab and pertuzumab) combined with chemotherapy for breast cancer

open access: yesWomen's Health, 2023
Background: Chemotherapy regimens containing a combination of anti-Her2 antibodies are effective but can be associated with cardiac toxicity. Objectives: We evaluate the outcome with a particular focus on the cardiac function of patients with Her2 over ...
Jamal Zekri   +6 more
doaj   +1 more source

Dynamic Trajectories of Left Ventricular Ejection Fraction in Heart Failure

open access: yesJournal of the American College of Cardiology, 2018
Long-term trajectories of left ventricular ejection fraction (LVEF) in heart failure (HF) are incompletely characterized.This study sought to examine LVEF trajectories in HF with reduced LVEF (
Javier Santesmases   +12 more
openaire   +9 more sources

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

open access: yesAdvanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang   +10 more
wiley   +1 more source

Differences in the clinical characteristics of patients with dilated cardiomyopathy, depending on the presence of preserved left ventricular contractile reserve assessed by exercise stress-echo-cardiography [PDF]

open access: yesPraxis Medica, 2014
Preserved left ventricular contractile reserve means the ability of poorly contractile myocardial segments to improve their contractility under the influence of different inotropic stimulus.
Perić V.   +10 more
doaj   +1 more source

KLF1 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through Regulation of Wnt/β‐Catenin Signaling Pathway

open access: yesAdvanced Science, EarlyView.
In KLF1‐on (neonatal and Klf1 overexpression hearts) models, KLF1 regulates Wnt/β‐catenin signaling pathway and the expression of cell proliferation‐related genes via transcriptional and epigenetic mechanisms, which induces cardiomyocyte proliferation and cardiac regeneration in mice after myocardial infarction.
Yanglin Hao   +19 more
wiley   +1 more source

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