Results 241 to 250 of about 128,502 (303)

Effects of soluble guanylyl cyclase stimulation on muscle oxygenation and exercise capacity in heart failure with mildly reduced ejection fraction

Experimental Physiology, EarlyView.
Abstract Heart failure (HF) with a mildly reduced ejection fraction (HFmrEF; 40%–49%) is present in ≤25% of HF patients. Therapeutic treatment options for HFmrEF‐associated exercise intolerance are limited. Nitric oxide (NO)‐independent stimulation of soluble guanylyl cyclase to improve peripheral vasodilatation offers a novel approach to enhance ...
Ramona E. Weber, Kiana M. Schulze, Andrew G. Horn, Tyler E. McCoach, Zachary J. White, K. Sue Hageman, Stephanie E. Hall, Peter Sandner, Brad J. Behnke, Timothy I. Musch, David C. Poole   +10 more
wiley   +1 more source

Human adaptation to high‐altitude: A contemporary comparison of the oxygen cascade in Andean, Tibetan and Ethiopian highlanders

Experimental Physiology, EarlyView.
Abstract Human populations native to high altitude have evolved distinct physiological adaptations to chronic hypoxia. This adaptation is evident in the O2 transport cascade. In this review, with brief inclusion of the related genetic adaptations, we compare the O2 cascade across three well‐characterized high‐altitude populations: Andeans (Aymara and ...
Ayechew A. Getu, Melissa Ilardo, Joshua C. Tremblay, Jay M. J. R. Carr, Vitalie Faoro, Philip N. Ainslie   +5 more
wiley   +1 more source

Influence of Echocardiographic Criteria on the Prevalence and Prognostic Implication of Left Ventricular Hypertrophy: A Nationwide Population-Based Study. [PDF]

J Am Heart Assoc
Cai A, Zheng C, Song Q, Qiu J, Wang X, Hu Z, Cao X, Tian Y, Gu R, Pei X, Yu X, Chang C, Tuerdi N, Zhang Y, Tian Y, Feng Y, Wang Z.   +16 more
europepmc   +1 more source

EuroSCORE II: Current limitations and physiological gaps in risk stratification

Experimental Physiology, EarlyView.
Abstract Risk stratification remains critical in cardiac surgery, enabling clinicians to predict adverse outcomes and guide perioperative management. The European System for Cardiac Operative Risk Evaluation (EuroSCORE) II, introduced in 2011, incorporates 18 key variables to provide an evidence‐based approach to risk assessment.
Jing Yong Ng, Eu Fon Tan, Marsioleda Kemberi, Eduardo Urgesi, Matti Jubouri, Damian M. Bailey, Mohamad Bashir, Wael I. Awad   +7 more
wiley   +1 more source

Diagnostic and prognostic value of ECG-predicted hypertension-mediated left ventricular hypertrophy using machine learning. [PDF]

J Hypertens
Naderi H, Ramírez J, Van Duijvenboden S, Ruiz Pujadas E, Aung N, Wang L, Chamling B, Dörr M, Markus MRP, Chahal CAA, Lekadir K, Petersen SE, Munroe PB.   +12 more
europepmc   +1 more source

Antenatal betamethasone impairs markers of cardiac development and function in near‐term lambs

Experimental Physiology, EarlyView.
Abstract figure Summary of key molecular differences in the left ventricle of near‐term lambs exposed to antenatal betamethasone, compared to saline. Pregnant ewes received two doses of either saline (Saline) or betamethasone (Betamethasone, intramuscular, 11.4 mg) given 24 h apart, before delivery at 140 days of gestation (dG, term = 150 dG).
Reza Amanollahi, Ashley S. Meakin, Stacey L. Holman, Vicki L. Clifton, Kent L. Thornburg, Michael D. Wiese, Kathryn L. Gatford, Mitchell C. Lock, Janna L. Morrison   +8 more
wiley   +1 more source

Distinct profiles of mitochondrial bioenergetics and redox balance in left atrial and ventricular myocardium in the healthy rat heart

Experimental Physiology, EarlyView.
Abstract The left ventricle (LV) is the primary pumping chamber of the heart, generating high systolic pressure to sustain systemic circulation. LV contractile dysfunction is a hallmark of various cardiovascular diseases and is associated with mitochondrial dysfunction, characterised by decreased oxidative phosphorylation (OXPHOS) capacity and ...
Tingting Fang, Alex Chan, Janice Chew‐Harris, Toan Pham   +3 more
wiley   +1 more source

Clinical significance of echocardiographic left ventricular hypertrophy for predicting left atrial appendage thrombotic milieu in patients with atrial fibrillation and CHA2DS2-VASc scores of 0–2

Kentaro Minami, Tomoko Machino‐Ohtsuka, Tomofumi Nakatsukasa, Naoto Kawamatsu, Kimi Sato, Masayoshi Yamamoto, Hiro Yamasaki, Yasushi Kawakami, Tomoko Ishizu   +8 more
openalex   +1 more source

Effects of high‐intensity interval training on cardiac function in hypertensive and normotensive men: Effects of antihypertensive treatment

Experimental Physiology, EarlyView.
Abstract Exercise training is recommended for individuals with hypertension because it has been shown to lower blood pressure and reverse left ventricular concentric remodelling and mass. However, it is unclear how hypertensive individuals respond in comparison to normotensive individuals and to what extent medical treatment affects the outcome of ...
Mads Fischer, Jon Egelund, Matteo Fiorenza, Thomas S. Ehlers, Michael Nyberg, Jesper J. Linde, Lasse Gliemann, Thomas P. Gunnarsson, Jens Bangsbo   +8 more
wiley   +1 more source

Determinants Influencing the Electrocardiographic Diagnosis of Left Ventricular Hypertrophy Among Hypertensive Patients. [PDF]

Cureus
Adalarasan S, S Y, Prabhakaran K, Rajkumar V, Shivamalarvizhi S, C H.   +5 more
europepmc   +1 more source