Results 251 to 260 of about 208,685 (341)

The Influence of Aldosterone on the Development of Left Ventricular Geometry and Hypertrophy in Patients With Essential Hypertension

, 2004
Ahmet Soylu, Ahmet Temizhan, Mehmet Akif Düzenli, G. Sökmen, Öznur Köylü, Hasan Hüseyin Telli   +5 more
openalex   +2 more sources

Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension

British Journal of Pharmacology, EarlyView.
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils‐Bonnet, Martin Wabitsch, Margaret R. MacLean   +12 more
wiley   +1 more source

Identifying PRKAG2 syndrome-a rare cause of wolff-Parkinson-white syndrome and left ventricular hypertrophy: a case report. [PDF]

Eur Heart J Case Rep
Jang JH, Baek YS, Jang WR, Kim DY, Shin SH.   +4 more
europepmc   +1 more source

Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Mavacamten (MAVA) is a novel small molecule inhibitor of cardiac myosin, mitigating cardiomyocyte hypercontractility in patients with hypertrophic obstructive cardiomyopathy (HOCM). Despite its recent approval for clinical use, the transcriptional and functional impacts of MAVA remain not well understood.
Elisa Kiselev, Wilson Agyapong, Bjarne Jürgens, Elisa Mohr, Shambhabi Chatterjee, Hannah J. Hunkler, Jawad Salman, Giuseppe Cipriano, Marco Bentele, Junqing Liu, Jonas Specht, Kaja S. Menge, Florian J. G. Waleczek, Jonas A. Haas, Anselm A. Derda, Kristina Sonnenschein, Anika Gietz, Susanne Neumüller, Angelika Pfanne, Oliver Beetz, Michael Pflaum, Bettina Wiegmann, Yiangos Psaras, Christopher Toepfer, Robert Zweigerdt, Ante Radocaj, Theresia Kraft, Andre Zeug, Evgeni Ponimaskin, Wilhelm Korte, Alexander Horke, Arjang Ruhparwar, Maximilian Fuchs, Ke Xiao, Christian Bär, Natalie Weber, Thomas Thum   +36 more
wiley   +1 more source

Left ventricular hypertrophy among adults in a population-based cohort in Haiti. [PDF]

Sci Rep
Ogyu A, Rouzier V, Sufra R, St Sauveur R, Jean-Pierre MC, Lin JQ, Mourra N, Preval F, Jean M, Devereux RB, Pirmohamed A, Goyal P, de Las Fuentes L, Dávila-Román VG, Alexandre W, Peck RN, Deschamps MM, Pape JW, McNairy ML, Yan LD.   +19 more
europepmc   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Left atrial volume index as an indicator of left ventricular diastolic dysfunction and hypertrophy

, 2014
Parijat Deb Choudhury, Ayan Kar, Debabrata Roy, Debika Chatterjee, Soumitra Kumar   +4 more
openalex   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Results of a Screening Program for Diagnosis of Amyloid Cardiomyopathy Among Patients with Left Ventricular Hypertrophy: PAPCAT Cardiac Amyloidosis Türkiye Survey. [PDF]

Anatol J Cardiol
Özpelit E, Çavuşoğlu Y, Babur Güler G, Ünlü S, Yıldırımtürk Ö, Çiçek Yılmaz D, Örem C, Başarıcı İ, Tüfekçioğlu O, Tokgözoğlu L, Karakulak UN, Dinçer İ, Çapa Kaya G, Ak Sivriöz İ, Murat S, Güler A, Çolak A, Şahin M, Kaplan E, Akaslan D, Türer Cabbar A, Sünbül M, Kaya Y, Zorkun CS, Vatansever Ağca F, İkitimur B, Onbaşılı A, Kılıçgedik A, Altay H, Eroğlu Büyüköner E, Değertekin M.   +30 more
europepmc   +1 more source

Relationship between plasma xanthine oxidoreductase activity and left ventricular ejection fraction and hypertrophy among cardiac patients

, 2017
Yuki Fujimura, Yohei Yamauchi, Takayo Murase, Takashi Nakamura, Shuichi Fujita, Tomohiro Fujisaka, Takahide Ito, Koichi Sohmiya, Masaaki Hoshiga, Nobukazu Ishizaka   +9 more
openalex   +2 more sources