Results 261 to 270 of about 208,685 (341)

Heart matters: How glucose‐ and lipid‐modulating drugs remodel epicardial adipose tissue accumulation, inflammatory patterns and browning

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot located between the myocardium and the visceral pericardium, exerting direct paracrine and vasocrine effects on the heart and coronary vessels. Under physiological conditions, EAT supports myocardial energy metabolism and thermoregulation through fatty acid supply and
Elisabeth Heuboeck   +2 more
wiley   +1 more source

Cardiovascular biomarkers and preeclampsia: A narrative review

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
Preeclampsia (PE) is a complex pregnancy disorder linked to cardiovascular disease (CVD) through shared risk factors and epidemiological associations. Cardiovascular biomarkers are valuable for predicting, diagnosing and assessing PE, as well as estimating future CVD risk. This review explores current cardiovascular biomarkers used in clinical practice
Johana Ullmo   +8 more
wiley   +1 more source

Long‐term effectiveness and safety outcomes in adults with Fabry disease treated with agalsidase alfa: 20 years of data from the Fabry Outcome Survey

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
Long‐term treatment with agalsidase alfa in 1864 adults with Fabry disease in the Fabry Outcome Survey confirmed previously reported beneficial effects on renal function and cardiomyopathy. Over a median (min, max) of 6.0 (0, 21.6) years of treatment, annualized changes in eGFR remained relatively stable in females and declined slightly in males.
Derralynn A. Hughes   +12 more
wiley   +1 more source

Hemodynamic and microcirculatory early adaptations following transcatheter aortic valve implantation (TAVI): A physiological pilot study

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
This pilot physiological study, involving 20 patients with severe aortic stenosis, shows that transcatheter aortic valve implantation (TAVI) induces rapid changes in both macrocirculatory parameters, reflecting the release of chronic obstruction. We observed improved tissue perfusion by postoperative Day 1, independent of macrocirculatory parameters ...
Stanislas Abrard   +12 more
wiley   +1 more source

IL‐6 in the spotlight: From cardiovascular pathophysiology to therapy

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
Interleukin‐6 (IL‐6) links inflammation to cardiovascular and multi‐organ dysfunction. This review integrates mechanistic, translational, and clinical evidence supporting IL‐6 as both a biomarker and therapeutic target in the continuum of cardiovascular and cardio‐renal disease.
Alberto Preda   +13 more
wiley   +1 more source

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