Results 311 to 320 of about 573,785 (398)

Vascular Endothelial NAMPT‐Mediated NAD+ Biosynthesis Regulates Angiogenesis and Cardiometabolic Functions in Male Mice

Aging Cell, EarlyView.
Using male vascular endothelial cell–specific Nampt knockout and naturally aged mice, we identified endothelial NAD+ deficiency as a central driver of age‐related angiogenic failure, impaired subcutaneous adipogenesis, and cardiometabolic dysfunction.
Shotaro Kosugi, Shintaro Yamaguchi, Ken Nishioka, Taichi Nagahisa, Yasuhiro Watanabe, Daiki Kojima, Kenji Kaneko, Ryunosuke Mitsuno, Ran Nakamichi, Yoshinaga Kawano, Kenichiro Kinouchi, Koichiro Homma, Takeshi Kanda, Junichiro Irie, Kazutoshi Miyashita, Toshiaki Monkawa, Jun Yoshino, Hiroshi Itoh, Kaori Hayashi   +18 more
wiley   +1 more source

Effects of Year Long Aerobic Exercise on Left Atrial Size in Patients With Left Ventricular Hypertrophy. [PDF]

Am J Cardiol
Kyrouac D, Talbot N, MacNamara J, Howden E, Hieda M, Hearon C, Brazile T, Levine B, Sarma S.   +8 more
europepmc   +1 more source

Entropy, Assessed by Homeostatic Dysregulation on Electrocardiograms Predicts Fracture and Mortality

Aging Cell, EarlyView.
Electrocardiogram‐based homeostatic dysregulation (ECG‐HD), a marker of cardiac conduction entropy, increases with age. Higher ECG‐HD is associated with a greater risk of aging outcomes including fractures and all‐cause mortality, independent of clinical risk factors, bone density, and ECG diagnoses.
Namki Hong, Sang Wouk Cho, Jungheui Kim, Hanjin Park, Dong‐Seon Kang, Seng Chan You, Hee Tae Yu, Kyoung Min Kim, Yumie Rhee, Alan A. Cohen, Steven R. Cummings   +10 more
wiley   +1 more source

Association between metabolic visceral fat score and left ventricular hypertrophy in individuals with type 2 diabetes. [PDF]

Diabetol Metab Syndr
Wang L, Liu S, Ke J, Cao B, Wang D, Zhao Q, Gong H, Fang Y, Zheng Z, Yu C, Wu N, Ma Y, Yu K, Yang L, Zhao D.   +14 more
europepmc   +1 more source

1275‐nm Photobiomodulation Alleviates Brain Drainage Impairment as a Promising Therapeutic Strategy for Aging‐Related Neurological Decline

Aging Cell, EarlyView.
Noninvasive 1275‐nm photobiomodulation improves brain drainage and promotes lymphatic clearance of advanced glycation end products (AGEs) in an aging model (AM) in male mice. These effects are associated with nitric oxide release‐mediated dilation of meningeal lymphatic vessels (MLVs).
Hao Lin, Shaojun Liu, Qihang Yang, Junming Li, Jue Wang, Oxana Semyachkina‐Glushkovskaya, Dongyu Li, Tingting Yu, Dan Zhu   +8 more
wiley   +1 more source

CCR2 dependent recruited pro-inflammatory monocytes contribute to the development of left ventricular hypertrophy in mice upon transverse aortic constriction. [PDF]

PLoS One
Eichhorn L, Kleiner JL, Bartsch B, Nazir MLF, Zhang Y, Coburn M, Frede S, Weisheit CK.   +7 more
europepmc   +1 more source

ISUOG Consensus Statement on maternal hemodynamic assessment in hypertensive disorders of pregnancy and fetal growth restriction

Ultrasound in Obstetrics &Gynecology, EarlyView.
T.  Stampalija, C.  Lees, T.  Ghi, J.  Cornette, W.  Gyselaers, E.  Ferrazzi, T.  Mousa, M.  Spaanderman, B.  Thilaganathan, H.  Valensise, Collaborators, J. J. Duvekot, C. Ghossein‐Doha, C. McEniery, F. Mecacci, G. P. Novelli, B. Vasopollo, I. Wilkinson   +17 more
wiley   +1 more source

Machine Learning‐Based Prediction of Life‐Threatening Complications During Hemodialysis in Hospitalized Patients With Poor General Conditions

Artificial Organs, EarlyView.
A machine learning model using predialysis data predicted sudden events during or after hemodialysis with high accuracy (auROC: 0.889). The key predictors included emergency hospitalization, recent surgery, high heart rate, low albumin levels, and high CRP.
Naotaka Kato, Takeshi Goto, Tomoyuki Ohira, Hirotaka Kinoshita, Kugo Kurokawa, Kouhei Naganuma, Chikako Ohminato, Junko Ogasawara, Shingo Hatakeyama, Yoshihiro Sasaki, Kazuyoshi Hirota, Chikara Ohyama   +11 more
wiley   +1 more source

Understanding the hidden burden: prevalence and factors linked to left ventricular hypertrophy in hypertensive patients receiving care in Harari region, Ethiopia. [PDF]

Front Cardiovasc Med
Tadesse A, Ayele ZA, Mekonnen MH, Mesfin S, Abebe D.   +4 more
europepmc   +1 more source

Increased ATP production and P‐glycoprotein activity underlie the marked changes in blood–brain barrier transport of drugs in a mouse model of amyotrophic lateral sclerosis

British Journal of Pharmacology, EarlyView.
Background and purpose Patients with amyotrophic lateral sclerosis (ALS) are prescribed many medications for symptomatic relief. However, how potential alterations to the blood–brain barrier (BBB) affect the brain exposure of drugs in ALS remains under‐investigated. Experimental approach We used high‐dimensional proteomic analysis, cellular metabolism,
Yijun Pan, Alanna G. Spiteri, Pranav Runwal, Jiaqi Sun, Dana S. Hutchinson, Yoshiteru Kagawa, Bradley J. Turner, Cheng Huang, Anup D. Shah, Ralf B. Schittenhelm, Joseph A. Nicolazzo   +10 more
wiley   +1 more source