Results 131 to 140 of about 5,439,136 (250)
Advanced Science, EarlyView.Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng +16 more
wiley +1 more source
Advanced Science, EarlyView.In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng +17 more
wiley +1 more source
Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation
Advanced Science, EarlyView.Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir +3 more
wiley +1 more source
Advanced Science, EarlyView.RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan +8 more
wiley +1 more source
Characteristics of Uremic Cardiomyopathy with Reversible Systolic Dysfunction [PDF]
, 2009 Background: There exists a sub group of patients with uremic cardiomyopathy who experience resolution of heart failure following hemodialysis.
Shamanna Iyengar, Srilakshmi Adhyapak
core
Advanced Science, EarlyView.This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu +12 more
wiley +1 more source
Advanced Science, EarlyView.A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang +10 more
wiley +1 more source
Advanced Science, EarlyView.Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu +11 more
wiley +1 more source
Turkish Journal of Nephrology, 2019 OBJECTIVE: To analyze the effect of peritoneal dialysis (PD) treatment on left ventricular systolic and diastolic function in patients with end-stage renal disease (ESRD).
Feridun KAVUNCUOĞLU +11 more
doaj
Macrophage GLUD1 is Essential for Redox Balance and Immune Homeostasis in Cardiac Injury
Advanced Science, EarlyView.Excessive free radical production and dysregulated immune responses are key contributors to myocardial ischemia‐reperfusion (IR) injury. Macrophage GLUD1 activity safeguards against HIF‐1α accumulation and maladaptive responses to IR‐induced ROS production.
Tingting Jin +16 more
wiley +1 more source