Results 71 to 80 of about 5,439,136 (250)

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Massa ventricular esquerda em portadores de insuficiência cardíaca Left ventricular mass in patients with heart failure

Arquivos Brasileiros de Cardiologia, 2004
OBJETIVO: Avaliar a massa ventricular esquerda em pacientes com insuficiência cardíaca, as correlações com outras variáveis clínicas e com o prognóstico.
Marcello Ricardo Paulista Markus, Humberto Felício Gonçalves de Freitas, Paulo Roberto Chizzola, Gisela Tunes da Silva, Antonio Carlos Pedroso de Lima, Alfredo José Mansur   +5 more
doaj   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Factors associated with diagnostic discrepancy for left ventricular hypertrophy between electrocardiography and echocardiography

Blood Pressure, 2017
Objective: To investigate the influence of cardiovascular risk factors, including fasting plasma glucose (FPG), on the association between electrocardiographic (ECG) and echocardiographic left ventricular hypertrophy (LVH) in an elderly population ...
Søren Sandager Petersen, Line Reinholdt Pedersen, Manan Pareek, Mette Lundgren Nielsen, Søren Zöga Diederichsen, Margrét Leósdóttir, Peter M. Nilsson, Axel Cosmus Pyndt Diederichsen, Michael Hecht Olsen   +8 more
doaj   +1 more source

Left ventricular hypertrophy and insulin resistance in adults from an urban community in The Gambia: cross-sectional study.

PLoS ONE, 2014
ObjectiveTo determine the association between left ventricular hypertrophy and insulin resistance in Gambians.DesignCross-sectional study.SettingOutpatient clinics of Royal Victoria Teaching Hospital and Medical Research Council Laboratories in Banjul ...
Bernard Cudjoe Nkum, Frank Botsi Micah, Theophilus C Ankrah, Ousman Nyan   +3 more
doaj   +1 more source

Relationship of Left Ventricular Mass with BMI and Insulin Resistance in Normotensive Obese Women

, 2016
Objective: Obesity is correlated with left ventricular mass (LVM) and insulin resistance (IR) and is an independent predictor of LVM in nondiabetic, non-hypertensive, obese people.
Feray Akbaş, Rengin Altınok, Esma Altunoğlu, Füsun Erdenen, Turgut Karabağ, Fatma Eda Nuhoglu Kantarcı, Duygu Şak   +6 more
core   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Effects of steady state free precession parameters on cardiac mass, function, and volumes. [PDF]

, 2007
PURPOSE: We aimed to investigate comparability of LV volumes, function, and mass acquired with three steady-state free precession (SSFP) pulse sequences, simulating typical vendor and protocol specific differences in data acquisition. METHODS: Twenty-one
Francis, JM, Hudsmith, LE, Neubauer, S, Petersen, SE, Robson, MD, Hogan, MC   +5 more
core   +1 more source