Results 221 to 230 of about 2,224,611 (335)

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan   +10 more
wiley   +1 more source

A Resistive Soft Robotic Exosuit for Dynamic Body Loading in Hypogravity

open access: yesAdvanced Science, EarlyView.
The resistive hypogravity exosuit is a lightweight wearable robotic exosuit that uses pneumatic artificial muscles to restore Earth‐like metabolic and muscular demands during locomotion in low gravity. Tested on healthy subjects in Earth and simulated Moon gravity, the suit restores energy expenditure and muscle activation without altering gait ...
Emanuele Pulvirenti   +6 more
wiley   +1 more source

S···O Conformation Locks Synergistic Alkoxy Chain Engineering of NIR‐II Phototheranostic Molecules for Precision Hepatocellular Carcinoma Theranostics

open access: yesAdvanced Science, EarlyView.
This study introduces a synergistic S‐O conformation locking and alkoxy chain engineering strategy to enhance S‐D‐A‐D‐S molecular planarity. The engineered IR‐BTOG achieves concurrent NIR‐IIa absorption and NIR‐IIb emission, demonstrating exceptional photothermal efficiency and fluorescence quantum yield.
Gui‐long Wu   +10 more
wiley   +1 more source

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