Results 31 to 40 of about 113,891 (261)

Homeostatic control of brain function – new approaches to understand epileptogenesis

Frontiers in Cellular Neuroscience, 2013
Neuronal excitability of the brain and ongoing homeostasis depends not only on intrinsic neuronal properties but also on external environmental factors; together these determine the functionality of neuronal networks.
Detlev eBoison, Ursula Susan Sandau, David N Ruskin, Masahito eKawamura, Susan A Masino   +4 more
doaj   +1 more source

A Morgan Legacy [PDF]

Genetics, 2020
Abstract The Thomas Hunt Morgan Medal recognizes lifetime contributions to the field of genetics. The 2020 recipient is Gerald R. Fink of Massachusetts Institute of Technology and the Whitehead Institute for Biomedical Research, recognizing the discovery of principles central to genome organization and regulation in eukaryotic cells.
openaire   +2 more sources

Geographic Differences in Availability and Access to Care Services for Asthma and COPD: Case Study of Vancouver Coastal Health, British Columbia

Canadian Respiratory Journal
Conclusion: Our findings suggest rural VCH communities have lower access to asthma and COPD care services and the limited urban care services were insufficient to make up for this difference.
Amelia Choy, Erin M. Shellington, Aneisha Collins-Fairclough, Nardia Strydom, Chris Carlsten   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Smart Solutions for Sustainable Cities—The Re-Coding Experience for Harnessing the Potential of Urban Rooftops

Applied Sciences, 2020
Urban rooftops are a potential source of water, energy, and food that contribute to make cities more resilient and sustainable. The use of smart technologies such as solar panels or cool roofs helps to reach energy and climate targets. This work presents
Valeria Todeschi, Guglielmina Mutani, Lucia Baima, Marianna Nigra, Matteo Robiglio   +4 more
doaj   +1 more source

Dermatomyositis Associated with Lung Cancer: A Brief Review of the Current Literature and Retrospective Single Institution Experience

Life, 2022
Dermatomyositis is a rare inflammatory myopathy that is often related to lung cancer. In this retrospective observational study, we analyzed data from patients diagnosed with lung cancer at Soroka University Medical Center between January 2017 and July ...
Walid Shalata, Jeremy Zolnoorian, Amichay Meirovitz, Kim Sheva, Ashraf Abu Jama, Omar Abu Saleh, Alexander Yakobson   +6 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Prevalence and determinants of hypertension in a rural community in southeastern Nigeria

Discover Public Health
Background Hypertension remains a major global public health challenge and a leading contributor to cardiovascular morbidity and mortality worldwide. The burden of hypertension is increasing rapidly in low- and middle-income countries, particularly in ...
Chidimma Ozoemena Nweke, Ebube Miracle Bernared, Ogechukwu Celestina Iloka, Onyekachukwu Nwabufoh, Rebecca Nkiru Sampson   +4 more
doaj   +1 more source

High-CBD Cannabis Vapor Attenuates Opioid Reward and Partially Modulates Nociception in Female Rats

Addiction Neuroscience, 2023
Chronic pain patients report analgesic effects when using cannabidiol (CBD), a phytocannabinoid found in whole-plant cannabis extract (WPE). Several studies suggest that cannabis-derived products may serve as an analgesic adjunct or alternative to ...
Maria T Rivera-Garcia, Rizelle Mae Rose, Adrianne R Wilson-Poe   +2 more
doaj   +1 more source