Results 121 to 130 of about 3,978,016 (307)

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

open access: yesAdvanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang   +5 more
wiley   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

open access: yesAdvanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo   +14 more
wiley   +1 more source

Legal Philosophy

open access: yes, 2022
In this chapter, we give an overview of some of the work on legal philosophy currently being done in the Netherlands. We explore: 1) work related to three classical approaches within legal philosophy: legal positivism, natural law theory and legal ...
Hondius, Ewoud   +4 more
core  

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen   +13 more
wiley   +1 more source

Feasibility of Group Legal Services in Australia: Survey of Solicitors Practising in Victoria, 1980

open access: yes, 2018
One of several surveys conducted for the 'Feasibility of group legal services in Australia' project, this survey examines the level of support from solicitors practising in Victoria for the introduction of group legal services and to assess solictors ...
Evans, John, Jones, Roger
core   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

open access: yesAdvanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang   +12 more
wiley   +1 more source

LEGAL BEHAVIOR, LEGAL VIOLATIONS AND LEGAL LIABILITY

open access: yes
LEGAL BEHAVIOR, LEGAL VIOLATIONS AND LEGAL LIABILITY Tashkent state agrarian university Faculty of Animal Engineering student, group 24-85, Rahimzhonova Mokhlaroy Teacher of Tashkent state agrarian  university  Otamurodova Salomat soloahmedovna@gmail ...
Rahimzhonova Mokhlaroy   +1 more
openaire   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

open access: yesAdvanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing   +10 more
wiley   +1 more source

Competitive Legal Professionals' use of Technology in Legal Practice and Legal Research

open access: yesPotchefstroom Electronic Law Journal/Potchefstroomse Elektroniese Regsblad, 2008
Advances in the information and communication technologies have led to the availability of a range of primary and secondary legal research publications online via the Internet, rather than on other storing devices such as compact discs or publications in the print media.
openaire   +6 more sources

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