Results 81 to 90 of about 4,412,705 (297)

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Legal Awareness in the Church, or the Awareness of the Church?

Kościół i Prawo, 2015
The article entitled “Legal Awareness in the Church, or the Awareness of the Church” presents the issue of the legal awareness of the members of the Catholic Church against the broader background of the awareness of the Church. Members of the Church are bound by the norms of both ecclesiastical and secular law, the latter setting out the norms for a ...
openaire   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

The Implementation of Islamic Law: the Problems of Changing of Legal Consciousness and Legal System of Russia

RUDN Journal of Law, 2018
The introduction of Islamic banking in the Russian financial sector raises issues related to the development of legislation, the adaptation of the principles of partner banking to the current rules of lending and investment, the problem of perceiving ...
Olga A Serova, Shifo A Niyatbekov
doaj   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

The Role of European Integration in the Development of Legal Awareness of the Ukrainian Society

Revista Jurídica Portucalense
This article deals with the role of European integration in shaping legal awareness in Ukraine. Its importance in the view of the current geopolitical changes is emphasized.
Victoria, Yevhen Novikov, Ivan Yakoviyk, Olesia Tragniuk, Maksym Sych   +4 more
doaj  

Ohio DDP and funding for individual options waiver

, 2006
Title from PDF cover (viewed on Jan. 22, 2007).; "September 2006"--P. 3 of cover.; Harvested from the web on 1/22/07Frequently asked questions about the Individual Options Waiver of the Ohio Developmental Disabilities Profile (ODDP) answered by the Ohio ...
Ohio Legal Rights Service.
core  

Legal Awareness and Practices of Female Genital Mutilation/Cutting (FGM/C) among United Arab Emirates Medical Practitioners. [PDF]

Int J Environ Res Public Health, 2023
Al Awar S, Zareba K, Sallam GS, Osman N, Ucenic T, Khair H, Shdefat SA, Fattah HA, Maki S.   +8 more
europepmc   +1 more source

Soft, Multi‐Wavelength Photoplethysmography Enables Reliable Neonatal Blood Pressure Monitoring Via Error Stratification

Advanced Science, EarlyView.
A soft hybrid multi‐wavelength PPG wearable acquires neonatal signals. Synchronized PPG and invasive ABP data are segmented into fixed windows. A 1D‐EfficientNet model predicts segment‐level SBP and DBP. Model performance is examined with retrospective subgroup analysis across acquisition conditions.
Wenqi Shi, Lanlan Mi, Jiarong Chen, Biao Liu, Min Wang, Zisheng Dai, Bin Liu, Ruize Gao, Yunfeng Lin, Weiwei Guo, Guoxing Wang, Wenyi Luo, Cheng Chen   +12 more
wiley   +1 more source

Strategy of civic education teachers in building awareness and legal compliance for the younger generation

Indonesian Journal of Social Sciences
The role of civic education teachers is profoundly strategic in fostering awareness and legal compliance among students. That is because civic education holds a mission and purpose to shape intelligent and virtuous citizens.
Handi Kurniyawan, Sri Wahyuni Tanshzil
doaj   +1 more source