Results 41 to 50 of about 76,495 (300)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Legal deposit libraries’ contribution to the Sustainable Development Goals

Information Research: An International Electronic Journal
Introduction. All types of libraries have a key role to play within the sustainability agenda. This paper mapped the main activities of legal deposit libraries in the UK to the United Nations Sustainable Development Goals (SDGs) to reveal how these ...
Ellie Jack, Gobinda Chowdhury
doaj   +1 more source

Applying Google Trends web-analytic tool to study the German legal deposit copy system

Библиосфера, 2019
The article «Applying Google Trends to study the German legal deposit copy system» discusses the use of web tools to investigate current library science problems.
S. V. Sokolov
doaj   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Transformation of Digital Legal Deposit in Terms of Legislation and Public Access

Knygotyra, 2018
[full article, abstract in English; abstract in Lithuanian] The age of digitization is marked by a huge quantity and variety of electronic content distributed on the Internet.
Georgi Alexandrov
doaj   +1 more source

Destruction of the legal deposit archives

, 2022
Une des sources majeures de l'histoire du livre en France au XX e siècle, les archives du dépôt légal (1925-1968), a été détruite le 11 août 2016 par la Bibliothèque nationale de France et les Archives nationales. L'analyse de l'histoire de ces archives et du processus qui a conduit à cette destruction soulève des questions sur les liens entre ...
openaire   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

The legal deposit system as an element of the national culture (based on materials of the round table «The 5^th anniversary of adoption of Novosibirsk region law “On legal deposit”»)

Библиосфера, 2014
Results of the discussion on the importance of the legal deposit system (LDS) for the library collections formation and book culture and evolution taken place at «round table» «The 5th anniversary of adoption of Novosibirsk region law “On legal deposit ...
N. I. Podkorytova, O. N. Alshevskya, N. M. Anfinogenova, S. A. Tarasova, D. M. Tsukerblat   +4 more
doaj  

Changing Practice in a National Legal Deposit Library [PDF]

, 2006
This two-part essay considers how digital culture has influenced ideas about permanence and looks at the change in collecting practice in a legal deposit library.
Mason, Ingrid
core  

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source