Results 151 to 160 of about 60,643 (299)

Respuestas Judiciales a la Violencia de Género: el Derecho como Discurso y Práctica Sociales (Judicial Responses to Gender-based Violence: The Law as Discourse and Social Practice)

open access: yesOñati Socio-Legal Series, 2015
Usually the studies on the legal system are limited to normative or jurisprudential analysis. However, long time ago, we know that to understand to the law needs to know its meanings, its previous values and also its speeches and practices; this is, to ...
Mariana N. Sánchez Busso
doaj  

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

open access: yesAdvanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang   +27 more
wiley   +1 more source

Can Machines Make Statements? On AI and Juridical Proof [PDF]

open access: yes
Seminari del Barcelona Institute of Analytic Philosophy. En aquest seminari focalitzat en Declaracions de fets en el discurs jurídic. En Giovanni Tuzet exposa amb el títol Les màquines poden fer declaracions?
Tuzet, Giovanni
core  

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

open access: yesAdvanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu   +8 more
wiley   +1 more source

Eco‐Friendly Solvent System for Inkjet Deposition of Wide Bandgap Perovskite Solar Cells Enabling Tandem Integration

open access: yesAdvanced Science, EarlyView.
The fabrication of wide‐bandgap perovskite thin films via green solvents integrated with inkjet printing is developed. Controlled crystallization of the perovskite layer is achieved by optimizing ink formulation and additive engineering, enabling power conversion efficiencies above 17% for single junctions and 28% for perovskite/silicon tandem solar ...
Uma Kousalya Dangudubiyyam   +12 more
wiley   +1 more source

StackingNet: Collective Inference Across Independent AI Foundation Models

open access: yesAdvanced Science, EarlyView.
ABSTRACT Artificial intelligence (AI) built on large foundation models has transformed language understanding, computer vision, and reasoning, yet these systems remain isolated and cannot readily share their capabilities. Coordinating the complementary strengths of independently developed, black‐box foundation models is essential for trustworthy ...
Siyang Li   +4 more
wiley   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

open access: yesAdvanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang   +22 more
wiley   +1 more source

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