Results 111 to 120 of about 9,002,186 (378)

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

open access: yesAdvanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li   +10 more
wiley   +1 more source

Bridging the Gap: Integrating Flipped Classrooms into Legal Education in Pakistan

open access: yesJournal of Legal Studies
The legal education map of Pakistan is plagued by a slew of hurdles, starting with outdated teaching approaches and poor resource provision. This article suggests including flipped classrooms in legal education and the functional outcome of this is to ...
Ali Muhammad Imran
doaj   +1 more source

St Vincent College: report from the Inspectorate (FEFC inspection report; 13/96 and 55/00) [PDF]

open access: yes, 2000
The Further Education Funding Council has a legal duty to make sure further education in England is properly assessed. The FEFC’s inspectorate inspects and reports on each college of further education according to a four-year cycle. This record comprises

core  

Integrated Microfluidic Platform for High‐Throughput Generation of Intestinal Organoids in Hydrogel Droplets

open access: yesAdvanced Science, EarlyView.
ABSTRACT Organoid research offers valuable insights into human biology and disease, but reproducibility and scalability remain significant challenges, particularly for epithelial organoids. Here, we present an integrated microfluidic platform that addresses these limitations by enabling high‐throughput generation of uniform hydrogel microparticles ...
Barbora Lavickova   +8 more
wiley   +1 more source

Legal Positivism, AI, and the Modern Legal Landscape: Challenges in Education, Research, and Practice

open access: yesActa Universitatis Lodziensis Folia Iuridica
In a world that is constantly evolving and modernising, new technologies and automation mean rapid progress in many areas of society, including law. This article aims to discuss whether artificial intelligence will have an impact on legal positivism by ...
Agnė Juškevičiūtė-Vilienė
doaj   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

open access: yesAdvanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen   +9 more
wiley   +1 more source

The Bank and Credit Union Disasters in Lithuania: Where Were the Lawyers?

open access: yesBaltic Journal of Law & Politics, 2014
Since Lithuania’s independence in 1991, sixteen banks in the country have gone bankrupt. From 2011 to 2013 two banks-the fifth and sixth largest banks in the country- went bankrupt and three credit unions collapsed.
Kiršienė Julija
doaj   +1 more source

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