Results 111 to 120 of about 63,181 (312)

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

Stages of the Creating the Legal Entity

, 2014
В статті розглядаються теоретичні та практичні аспекти створення юридичної особи, надалі розвинута та уточнена раніше висунута автором концепція стадій створення юридичної особи та зміст кожної із них. Виділено ініціативну, організаційну та легалізаційну
Шишка, Р., Shyshka, R.
core  

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Practice, knowledge and attitude of physicians and pharmacists towards the spontaneous reporting system of adverse drug reactions in Switzerland

British Journal of Clinical Pharmacology, EarlyView.
Introduction Introduction Reporting adverse drug reactions (ADRs) is essential for detecting drug risks. Despite legal obligations in Switzerland, underreporting remains an issue. This study assessed practice, knowledge and attitudes towards the spontaneous ADR reporting system among physicians and pharmacists.
Fiona A. Strobel, Thomas Stammschulte, Patrick E. Beeler   +2 more
wiley   +1 more source

Features of legal personality of a legal entity [PDF]

, 2018
Парасюк В.М. Особливості правосуб’єктності юридичної особи / Парасюк В.М., Парасюк М.В. // Visegrad Jurnal on Human Rights. - 2018. - № 2. - С. 139-145.Статтю присвячено питанням структури та співвідношення елементів цивільної правосуб’єктності ...
Parasiuk, V.M., Парасюк, М.В., Парасюк, В.М., Parasiuk, M.V.   +3 more
core  

‘Where are the adults?’: Troubling child‐activism and children's political participation

British Educational Research Journal, EarlyView.
Abstract Children's political participation is a well‐established theme in childhood studies. In this article we offer an original account of child activism that takes into account the entangled and emergent aspect of children as activists. We begin with a historical and a conceptual review, noting the importance of mid‐20th century developments such ...
Sharon Hunter, Claire Cassidy
wiley   +1 more source

Tax Optimization of the Legal Entity Income

, 2016
This bachelor´s thesis is focused on the tax optimization of the selected legal entity. It provides theoretical knowledge of corporate tax in selected countries: Czech Republic, Slovak Republic, Hungary, Austria and Germany, and practical calculations of
Gonová, Lucia
core  

PROBLEMS OF LEGAL REGULATION OF LEGAL ENTITIES IN KAZAKHSTAN

Journal of Foreign Legislation and Comparative Law, 2016
This article deals with the issues related to the establishment of the legislation on legal entities in Kazakhstan, beginning with the 1991 Law on Enterprises and ending with the Laws enacted on the basis of the Civil Code of the Republic of Kazakhstan.
openaire   +1 more source

The future in a bubble: Supporting Finnish early childhood professionals working in diverse settings

British Educational Research Journal, EarlyView.
Abstract The purpose of this study was to contribute to the knowledge about early childhood education and care (ECEC) personnel's perception of the support structures that are most effective in assisting them in their work with culturally and linguistically diverse children.
Alexandra C. Anton, Juli‐Anna Aerila, Elizabeth A. Steed   +2 more
wiley   +1 more source