Results 91 to 100 of about 344,184 (303)
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome
Advanced Science, EarlyView.We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu +19 more
wiley +1 more source
Social Networking and Judicial Ethics
, 2012 Social media, like any public communication form, presents special ethical challenges for judges. In recent years, judicial ethics committees in various states have weighed in on these questions and have not shown any clear consensus.
Estlinbaum, Craig, Craig Estlinbaum
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G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
The Agony of Modern Legal Ethics, 1970–1985
, 2014 When the American Bar Association (ABA) adopted its Code of Professional Responsibility at its annual meeting in August 1969, the American legal profession was a publicly respected and economically vibrant body.
Ariens, Michael S +2 more
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Advanced Science, EarlyView.The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi +8 more
wiley +1 more source
Introduction [Reaffirming Legal Ethics: taking stock and new ideas]
, 2010 The contributors to this book reaffirm legal ethics. In doing so, they enable us to take stock of current thinking about the conduct of lawyers. All of the contributors assert, in no uncertain terms, the ongoing importance of legal ethics both as a ...
Robertson, Mike +5 more
core +1 more source
Judges under corruption stress
Oñati Socio-Legal SeriesJudicial corruption represents a critical issue for proper functioning of the rule of law and democracy. I explore the topic of judicial corruption and the role judges and lawyers may play in it in Slovakia.
Jan Mazur
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng +15 more
wiley +1 more source
Professional legal ethics in Australia [PDF]
, 2018 The paper is an account of the deep moral structures of Australian legal professions, grounded in political and philosophical ...
Mortensen, Reid
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