Results 31 to 40 of about 1,710 (167)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

open access: yesAdvanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng   +8 more
wiley   +1 more source

NOTARIZED MINUTES AS INSTRUMENTS OF EVIDENCE IN FUNDAMENTAL PROCEDURAL LAW BEFORE THE VOLATILITY OF FACTS IN CYBERSPACE

open access: yesRevista Eletrônica de Direito Processual, 2020
Before the profuse number of possibilities of legal facts taking place in cyberspace, one questions how to measure qualified evidence value for such occurrences in potential lawsuits.
Luiz Gonzaga Silva Adolfo   +1 more
doaj   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

open access: yesAdvanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun   +27 more
wiley   +1 more source

GENERALLY KNOWN FACTS IN LITIGATION

open access: yesZbornik Pravnog Fakulteta Sveučilišta u Rijeci, 2017
This paper deals with generally known facts in litigation with review on some viewpoints accepted in Austrian, German and Croatian jurisprudence and legal practice on this topic.
Mihajlo Dika
doaj  

Legal Norms in the Focus of the Constructivism Theory

open access: yesТеоретическая и прикладная юриспруденция, 2020
The author, based on the theory of constructivism, explores the central concept of law — the legal norm. A consistent deconstruction of the legal norms is carried out, which allows us to distinguish three of its components: “Normative proposition” or ...
O. Khalabudenko
doaj  

Femtosecond‐Laser‐Induced Physical Unclonable Random Maze Structure for Storage‐Free Encryption

open access: yesAdvanced Science, EarlyView.
Femtosecond‐laser‐induced gold random maze structures serve as multimodal physical unclonable functions for storage‐free encryption. Their stochastic optical, electrical, and Raman responses are generated by plasmon‐assisted Marangoni formation and converted into AES‐compatible keys without permanent secret‐key storage, offering a portable route toward
Shiru Jiang   +6 more
wiley   +1 more source

Hubungan Logika Hukum dengan Argumentasi Hukum melalui Penalaran Hukum

open access: yesNagari Law Review, 2019
Logic is a thinking activity to do systematic reasoning to produce conclusions which are the art of thinking in a straight, precise and orderly manner. Logical nature is a special nature of law which means that in a reciprocal relationship between legal ...
Misnar Syam, Yasniwati Yasniwati
doaj   +1 more source

Labeling Quality or Quantity? The Differential Impact of Geographical Indications on Export Performance in Turkish Agri‐Food Products

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT This study investigates the impact of geographical indication (GI) certification on the export performance of Turkish agri‐food products by analyzing both trade volume and unit value dynamics. Drawing on monthly data from 2000 to 2024 across 22 GI‐certified products, the research employs product‐level regressions, fixed‐effects panel models ...
Ihlas Sovbetov, Muge Burcu Ozdemir
wiley   +1 more source

THE IMPORTANCE OF EVENTS AS LEGAL FACTS

open access: yesIustinianus Primus Law Review, 2015
In civil law there are vast number of legal fact1 that individually or as a group of facts have an effect on civil law relations, those legal facts lead to creation, change or dissolution of civil law relations.
Rodna Zivkovska
doaj  

How Video‐Based Information Affects Farmers' Willingness to Pay for Drone Services

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT Professional service for digital technology like agricultural drones lowers transaction costs and scope thresholds for smallholders. Meanwhile, perceptual adoption barriers remain underexplored. We conduct a two‐stage choice experiment with a randomized video‐based information treatment among 384 Chinese crop farmers to measure its effect on ...
Hua Zhang   +4 more
wiley   +1 more source

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