Results 111 to 120 of about 6,461,136 (249)

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen   +13 more
wiley   +1 more source

Pseudolaw and the illusion of legal meaning [PDF]

open access: yesAlternative Law Journal
This article is an overview of the contemporary phenomenon of pseudolaw and argues that, at its heart, it involves a mistaking of the form of legal argumentation for its substance. Essentially, through the use of legalistic language, archaic sources and strange rituals, an illusion of legal meaning is created which tricks users into believing their ...
openaire   +1 more source

Children's rights the rights of children and their families who need or are receiving community services.

open access: yes, 2006
Title from cover (i.e. p. [1]) of PDF document (viewed July 28, 2006).; "This publication was produced by Ohio Legal Rights Service through a contract with National Alliance on Mental Illness (NAMI) Ohio and with funding from the Ohio Department of ...
Ohio Legal Rights Service.
core  

Boulder Statement on Legal Research Education [PDF]

open access: yes, 2009
The Conference on Legal Information: Scholarship and Teaching was attended by legal research professionals who gathered at the University of Colorado Law School in Boulder, Colorado on June 21-22, 2009, to discuss legal information scholarship and ...
Legal Information Conference Attendees
core  

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

open access: yesAdvanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing   +10 more
wiley   +1 more source

Providing digital security of healthcare system with criminal-legal means

open access: yesRussian Journal of Economics and Law
Objective: to develop a comprehensive system of ethical principles for the formation of a regulatory framework and the practical implementation of digital bioprinting technologies in clinical practice.Methods: the research is based on the application of ...
A. A. Shutova, I. R. Begishev
doaj   +3 more sources

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

open access: yesAdvanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang   +27 more
wiley   +1 more source

The Legal Limits of “Yes Means Yes” [PDF]

open access: yes, 2016
This op-ed piece for the Chronicle of Higher Education argues that the affirmative consent rule of yes means yes is a useful standard that can help educate and ideally change norms regarding consent to sexual intercourse.
Robinson, Paul H.
core  

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

open access: yesAdvanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu   +8 more
wiley   +1 more source

Eco‐Friendly Solvent System for Inkjet Deposition of Wide Bandgap Perovskite Solar Cells Enabling Tandem Integration

open access: yesAdvanced Science, EarlyView.
The fabrication of wide‐bandgap perovskite thin films via green solvents integrated with inkjet printing is developed. Controlled crystallization of the perovskite layer is achieved by optimizing ink formulation and additive engineering, enabling power conversion efficiencies above 17% for single junctions and 28% for perovskite/silicon tandem solar ...
Uma Kousalya Dangudubiyyam   +12 more
wiley   +1 more source

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