Results 131 to 140 of about 10,553,855 (390)

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Formation and Development of the Organizational and Legal Mechanism for the Protection of Human Information Rights and Freedoms in Ukraine

Theory and Practice of Public Administration
The article is devoted to the formation and development of the organizational and legal mechanism for the protection of information rights and human freedoms in Ukraine.
Lesja Vasilieva, Andrii Puhach
doaj   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

MECHANISM OF REALIZAION OF DISPOSITION AND SANCTION OF THE PROHIBITIVE LEGAL NORM

Russian Journal of Economics and Law, 2012
The article presents the theoretical-legal analysis of the stages of a mechanism of prohibitive legal norm realization. The authors distinguish the mechanisms of prohibition (disposition) realization and sanction realization, which together form the ...
N. N. Rybushkin, A. V. Krasnov
doaj  

Corporate Governance and Incentive Contracts: Historical Evidence from a Legal Reform [PDF]

This paper proposes to exploit a reform in legal rules of corporate governance to identify contractual incentives from the correlation of executive pay and firm performance.
Carsten Burhop, Christian Bayer
core  

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

Advanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, Lin Li, Tao Liu   +11 more
wiley   +1 more source

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

OPTIMIZATION OF THE LEGAL REGULATION IN THE CONTEXT OF SOCIAL-ECONOMIC DEVELOPMENT

Russian Journal of Economics and Law, 2015
Objective: to develop conceptual theoretical-legal provisions and scientific recommendations to optimize legal regulation and increase efficiency of public administration.
Y. A. Tikhomirov
doaj  

Confucian Virtue Jurisprudence [PDF]

, 2012
Virtue jurisprudence is an approach to legal theory that develops the implications of virtue ethics and virtue politics for the law. Recent work on virtue jurisprudence has emphasized a NeoAristotelian approach. This essay develops a virtue jurisprudence
Solum, Lawrence B., Wang, Linghao
core   +1 more source

Countering Transnational Shadow Economy Crime: Mutual Legal Assistance Mechanism [PDF]

, 2023
Wita Setyaningrum, Ridhayana Andi Baso, Muhammad Anshar Nur, Mufti Khakim   +3 more
openalex   +1 more source