Results 141 to 150 of about 10,553,855 (390)

Integrated Microfluidic Platform for High‐Throughput Generation of Intestinal Organoids in Hydrogel Droplets

open access: yesAdvanced Science, EarlyView.
ABSTRACT Organoid research offers valuable insights into human biology and disease, but reproducibility and scalability remain significant challenges, particularly for epithelial organoids. Here, we present an integrated microfluidic platform that addresses these limitations by enabling high‐throughput generation of uniform hydrogel microparticles ...
Barbora Lavickova   +8 more
wiley   +1 more source

Legal regulation and impact: Hard and soft forces in commemoration of Sergei S. Alexeev’s Centenary

open access: yesRUDN Journal of Law
The article characterizes and schematizes the central legal category of the “mechanism of legal regulation” (MLR), as originally formulated by S.S. Alekseev in 1966.
Tatyana V. Kashanina
doaj   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

open access: yesAdvanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen   +9 more
wiley   +1 more source

Development and the Interaction of Enforcement Institutions [PDF]

open access: yes
We examine how institutions that enforce contracts between two parties, producers and consumers, interact in a competitive market with one-sided asymmetric information and productivity shocks. We compare an informal enforcement mechanism, reputation, the
Dhillon, Amrita, Rigolini, Jamele
core  

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

open access: yesAdvanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang   +15 more
wiley   +1 more source

Social and legal regulators. Conceptual developments by V.I. Nizhechek

open access: yesRUDN Journal of Law
The role of the Soviet scientist-activist V.I. Nizhechek in the development and establishment of social regulation concepts, and its importance in governing societal affairs, as well as functions and potential of law, and its relationship with morality ...
Nikolai A. Vlasenko
doaj   +1 more source

Information Transmission in Emerging Markets: The Case of a Unique Financing Instrument [PDF]

open access: yes
Information flows are necessary for well-functioning financial markets. However, in many emerging markets, the legal and institutional preconditions for proper information flow are not met. How do such markets respond?
Siddiqi, Hammad
core   +1 more source

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

open access: yesAdvanced Science, EarlyView.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu   +8 more
wiley   +1 more source

The relation between dividends and insider ownership in different legal systems: international evidence [PDF]

open access: yes
This paper provides new international evidence on the relationship between dividend policy and insider ownership by analysing a sample of firms from countries characterised by an Anglo-Saxon tradition and a matching sample of companies from countries ...
Jorge Farinha, Óscar López de Foronda
core  

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