Results 71 to 80 of about 5,657,445 (266)

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

The eristic of newsworthiness in the representation of Barnevernet controversy: A case study of the Norwegian Child Welfare Service

Res Rhetorica, 2018
This study offers a critical evaluation of news values by four selected contemporary media outlets: BBC News, The Federalist, OneEurope and Dagbladet. The material covers the controversy around the Norwegian Child Welfare Service with cases of children ...
Klaudia Szyma
doaj   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Assessing the Legitimacy of Penalising Media Organisations for Disseminating ‘Fake News’ [PDF]

E-Journal of Humanities, Arts and Social Sciences
The purpose of this study was to explore the complex and evolving issue of penalising media organisations for the dissemination of ‘fake news’ in the digital age.
Bulelani Thukuse
doaj   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

A Method for Analyzing News Themes Involving Cases with Integrated Crime Classification [PDF]

Jisuanji gongcheng
This paper discusses the significance of crime news topic analysis and identifies the limitations of existing methods. The paper presents a novel topic analysis model called the Bidirectional Encoder Representations from Transformers-based Embedded Crime
YIN Zhaoliang, HUANG Yuxin, YU Zhengtao, WANG Guanwen, AI Chuanxian
doaj   +1 more source

Entanglements in Legal History [PDF]

, 2014
"Legal History presents a broad panorama of historical processes that trigger theoretical reflections on legal transfers and legal transplants and on the problem of the reception and assimilation laws and other modes of normativity. In this volume, legal
Castro, Fernández, Bandeira, Galindo, Srikantan, Geetanjali, Buis, Emiliano J, Zimmermann, Eduardo, Delbecke, Bram, Pifferi, Michele, Andrés Santos, Francisco J., Parise, Agustín, Heimbeck, Lea, Rodrigo, George, Belem, Ana, Kroppenberg, Inge, Linder, Nikolaus, Donlan, Seán Patrick, Duve, Thomas, Zollmann, Jakob, Kemme, Clara   +17 more
core   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Imbalanced media portrayal: a content analysis of precision medicine in US news of 2015–2021

Frontiers in Communication
IntroductionEngaging diverse participants is vital to precision medicine (PM) but has been limited by low knowledge and concerns about various issues related to PM research.
Wei Peng, Hae Yeon Seo, Juwhan Choi, Xiaofeng Jia   +3 more
doaj   +1 more source