Results 101 to 110 of about 624,417 (310)
Advanced Science, EarlyView.Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao +11 more
wiley +1 more source
Custom, Contract, and Kidney Exchange [PDF]
, 2012 In this Essay, we examine a case in which the organizational and logistical demands of a novel form of organ exchange (the nonsimultaneous, extended, altruistic donor (NEAD) chain) do not map cleanly onto standard cultural schemas for either market or ...
Healy, Kieran, Krawiec, Kimberly D.
core +2 more sources
Advanced Science, EarlyView.The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li +10 more
wiley +1 more source
Revista Direito MackenzieThe present article argues in favour of global coherence in judicial legal reasoning while criticizing ontological and justificatory coherence theories in law.
Daniela Gueiros Dias
doaj
Declarative Speech Act as Form of Regulation in Russian Penitentiary Law of the Early 19th Century
Научный диалог, 2018 The article is devoted to the description of speech forms of expression of legal norms in the penitentiary law of the first quarter of the 19th century.
L. M. Golikov
doaj +1 more source
Civilising Globalism: Transnational Norm-Building Networks—A Research Programme [PDF]
Decentralised, self-organised cross-border activities are increasingly shaping global policymaking. While state actors have lost ground, policy and economic networks have emerged as key actors, transforming international relations as well as national ...
Ulrich Mückenberger
core
Moral Norms and the System of Legal Norms. Legal Ethics
, 2020 ABSTRACT: For a long time, after the appearance of man on Earth, the human being lived in disorder, relying only on animal instincts, strictly satisfying his primary needs for food, shelter and reproduction. Evolution, however, forced him to adopt another way of life, the social one, settling and grouping in systems of administrative organization ...
openaire +1 more source
Advanced Science, EarlyView.PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li +8 more
wiley +1 more source
THE RATIONALE OF LAW. THE ROLE AND IMPORTANCE OF THE LOGICAL METHOD OF INTERPRETATION OF LEGAL NORMS [PDF]
Challenges of the Knowledge Society, 2017 The interpretation of law was and remains an indispensable postulation, inherent and the most significant in the application of the law. Through interpretation the aim is to clarify the obscure text, to rectify the imperfection of the text of the legal ...
Mihai BĂDESCU
doaj
PRINSIP-PRINSIP KONTRAK KONSTRUKSI INDONESIA
Mimbar Yustitia: Jurnal Hukum dan Hak Asasi Manusia, 2018 The implementation of construction services must meet the principles of honesty and fairness, benefits, compatibility, balance, independency, openness, partnership and safety foremost in the interest of the community, nation and the state ( article 2 act
Sugiarto Raharjo Japar, SRJ
doaj +1 more source