Results 111 to 120 of about 16,631 (259)

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

No Apologies? The Role of Apology for Structural‐Historical Injustice

Journal of Applied Philosophy, EarlyView.
ABSTRACT During this era of political apologies, a new literature has emerged in historical injustice interrogating the relationship between structural and historical injustice, with various theories conceptualising the relationship in different ways. Interestingly, ‘apology’ rarely appears in this literature.
Maeve McKeown
wiley   +1 more source

Unlocking Value Co‐Creation in IoT Platforms: Insights From a Collaborative Manufacturing Case

Strategic Change, EarlyView.
ABSTRACT This study examines value co‐creation in IoT platform ecosystems through a case study of the collaborative manufacturing platform E‐LINK. We explore the evolution of platform data capabilities, user interactions, value creation, and the mechanisms that connect them.
Huayao Zhang, Junjie Wu, George Lodorfos, Mingyao Sun, Mickaël Naulleau   +4 more
wiley   +1 more source

Dynamic Capabilities Under Constraint: Extending Teece's Framework Through Contextualized Micro Foundations and Capability Elasticity

Strategic Change, EarlyView.
ABSTRACT Dynamic capabilities research has made significant progress in explaining firm adaptation under environmental change, yet existing frameworks largely assume conditions of resource abundance and institutional stability. This paper develops a theory‐extending framework that explains how small and medium‐sized enterprises (SMEs) operating under ...
Ntandoyenkosi Sibindi, Fungai Chiruka
wiley   +1 more source

An Ontology for Workplace Violence: Protocol to Support Cross-Sector Incident Reporting in Public Services. [PDF]

JMIR Res Protoc
Steenhout I, Buyl R.
europepmc   +1 more source

Shadow Learning and Knowledge Redistribution: How Workers Appropriate Generative AI Outside Formal Organisational Systems

Knowledge and Process Management, EarlyView.
ABSTRACT Organisations are ceding visibility over how their employees develop knowledge. As generative AI tools become widely accessible, workers are steadily building capabilities and co‐producing knowledge through informal AI engagements that operate entirely outside sanctioned training systems.
Eduardo Carlos Dittmar, Martin Sposato
wiley   +1 more source

From free text to structured genomics: future-proofing cancer registries for precision oncology. [PDF]

ESMO Real World Data Digit Oncol
Zohner J, Kuhl C, Schmid K, Kim-Wanner SZ, Kujawa C, Amsel D.   +5 more
europepmc   +1 more source

Mass Spectrometry in Authentication and Forensic Approaches for Determining the Origin of Hazardous Chemicals

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Identification of a chemical agent yields insights into its physicochemical properties. By examining the intrinsic characteristics and environment of a compound, information about its history can be gathered. The main objective of authentication/forensic approaches to chemicals is to trace the history of the compound's origin, regardless of ...
Carla Orlandi, Grégoire Delaporte, Christine Albaret, Emmanuel Joubert, Anne Bossée, Emilien L. Jamin, Laurent Debrauwer   +6 more
wiley   +1 more source

Automated regulatory compliance for AI systems in the security domain: The case of dual-use deployment. [PDF]

Open Res Eur
Sabaliauskaite G, Paskauskas RA, Bružė E, Matulytė R, Lavišius T.   +4 more
europepmc   +1 more source